| Objective To analyze the relationship between serum multiligand proteoglycan 4 (Syndecan-4) and elabela levels and the degree of carotid artery stenosis and its poor prognosis in patients with cerebral infarction. Methods 400 patients with cerebral infarction admitted to our hospital from January 2020 to December 2022 were selected, and all patients were divided into mild stenosis group (103 cases), moderate stenosis group (64 cases), severe stenosis group (33 cases), and no stenosis group (200 cases) based on their conditions, as well as prognosis was divided into two groups: poor prognosis group (160 cases) and good prognosis group (240 cases). Enzyme linked immunosorbent assay (ELISA) was applied to detect the levels of serum Syndecan-4 and elabela, Risk factors for poor patient prognosis were analyzed by logistic method; ROC was applied to analyze the predictive value of serum Syndecan-4 and elabela for poor prognosis. Results The expression levels of Syndecan-4 and elabela in the non stenosis group, mild stenosis group, moderate stenosis group, and severe stenosis group gradually increasedin the serum of patients with cerebral infarction(P<0.05). There were obvious differences in hypertension, diabetes, atrial fibrillation, the levels of serum Syndecan-4 and elabela between good prognosis group and poor prognosis group (P<0.05). Higher levels of Syndecan-4 and elabela in the serum of patients with cerebral infarction were significant risk factors for their poor prognosis (P<0.05). The area under the curve (AUC) of serum Syndecan-4, elabela, and their combination in predicting poor prognosis in patients with cerebral infarction was 0.734, 0.782, and 0.840, respectively, the predictive value of the combination of the two was better than that of serum Syndecan-4 and elabela alone (Z combination-Syndecan-4=5.210, P<0.001; Z combination-elabela=3.178, P=0.002). Conclusion Serum Syndecan-4 and elabela levels are associated with carotid artery stenosis in patients with cerebral infarction, and the combination of the two has a higher predictive power for poor prognosis in patients with cerebral infarction. |