|
| 缺血性脑卒中急性期抑郁状态与1年后认知及生活功能的相关性研究 |
| Correlation between Depressive Symptoms in Acute Phase of Ischemic Stroke and Cognitive and Life Function One Year later |
| 投稿时间：2025-03-07 修订日期：2025-03-07 |
| DOI： |
| 中文关键词: 急性缺血性脑卒中 抑郁状态 认知障碍 生活功能 |
| 英文关键词: Acute ischemic stroke Depressive symptoms Cognitive impairment life function |
| 基金项目:国家重点研发计划（卒中后抑郁的多维度筛查防治技术开发与应用-卒中后抑郁危险因素预测评估批准号2017YFC1310000） |
|
| 摘要点击次数: 47 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨缺血性脑卒中急性期抑郁状态与1年后认知及生活功能的相关性,为卒中后抑郁状态(PSDS)的早期干预提供临床依据。方法：收集2018年6月至2019年6月在武汉市中心医院及华中科技大学同济医学院附属同济医院住院的急性缺血性脑卒中(AIS)患者的临床资料。出院时,采用流调中心抑郁自评量表(CES-D)评估卒中后抑郁状态的程度。随访1年,采用简易精神状态量表(MMSE)评估认知功能,采用改良的Rankin量表(mRS)评估生活功能。运用多因素Logistic回归分析PSDS与卒中1年后功能预后的相关性。 结果：共纳入219例AIS患者,根据卒中急性期是否有抑郁状态分为PSDS组和非PSDS组。基线数据分析显示,PSDS组的BMI及卒中类型与非PSDS组相有显著差异(P＜0.05)。多因素Logistic回归分析结果显示,与非PSDS组相比,PSDS组在卒中1年后认知障碍患者的比例更低(P＜0.001),在mRS良好预后的比例上,两组之间没有显著差异。结论：本研究发现缺血性脑卒中急性期抑郁状态与卒中1年后发生认知障碍的风险升高显著相关,与良好生活功能预后无显著相关性。 |
| 英文摘要: |
| Objective: To explore the correlation between depressive symptoms in patients with acute ischemic stroke (AIS) and prognosis of cognitive and life function, and to provide clinical basis for early intervention of post-stroke depressive symptoms (PSDS). Method: We collected the clinical data of patients with acute ischemic stroke (AIS) hospitalized in Wuhan Central Hospital and Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of science and technology from June 2018 to June 2019. At discharge, the severity of post-stroke depressive symptoms was assessed using Center for Epidemiological Studies Depression Scale (CES-D). At one-year follow-up, cognitive function was assessed using the Mini-Mental State Examination (MMSE), and life function was assessed using the modified Rankin Scale (mRS). The correlation between PSDS and clinical outcome one year after stroke was analyzed using multifactorial logistic regression. Result: A total of 219 AIS patients were included and divided into PSDS group and non PSDS group according to whether there was PSDS in the acute phase of stroke. Baseline data analysis showed that BMI and stroke types in the PSDs group were significantly different from those in the non PSDs group (P<0.05). Multivariate logistic regression analysis showed that compared with the non PSDs group, the PSDs group had a lower proportion of patients with cognitive impairment one year after stroke (P<0.001), and there was no significant difference in the proportion of mRS with good prognosis between the two groups. Conclusion: This study found that depressive symptoms in the acute phase of ischemic stroke was associated with an increased risk of cognitive impairment one year after stroke, and had no significant correlation with the prognosis of good life function. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |