| Objective:To evaluate the correlation between platelet/lymphocyte ratio（PLR）with hemorrhagic tromsformation（HT）and prognosis in elderly patient with acute ischemic stroke（AIS）after rt-PA intravenous thrombolysis. Methods:132 elderly AIS patients were selected as the study objects, divided into HT group (n=21) and non-HT group (n=111) according to whether HT occurred. The general data and laboratory indicators were compared between two groups. Logistic regression was used to analyze the influencing factors of HT after intravenous thrombolytic therapy, and ROC was used to analyze the predictive value of PLR for HT after intravenous thrombolytic therapy. The difference in 90d neurological function prognosis of patients with different levels of PLR was compared. Results:The NIHSS score, time from onset to thrombolysis, atrial fibrillation, PLT and PLR of HT group were higher than non-HT group, and LYW was lower than non-HT group（P＜0.05）. There were no significant differences in gender, age, BMI, lesion site, smoking, drinking, coronary heart disease, hypertension, diabetes, stroke or TIA history, SBP, DBP, FBG, Hcy, TG, TC, LDL-C, HDL-C, RBC and WBC between two groups（P＞0.05）. Logistic regression analysis showed that NIHSS score, time from onset to thrombolysis, atrial fibrillation and PLR were risk factors for HT after intravenous thrombolysis in AIS patients. ROC curve analysis results showed that PLR predicted the truncation value of HT after intravenous thrombolysis in AIS patients was 147.415, the area under the curve was 0.807, the sensitivity was 76.2%, and the specificity was 82.9%. The incidence of poor neurological function prognosis at 90 days in the high PLR group was higher than low PLR group（P＜0.05）. Conclusion:PLR is associated with poor prognosis and HT of elderly AIS patients after rt-PA intravenous thrombolysis, and has good predictive value for HT. |