文章摘要
重症肌无力与膈肌关系的研究进展
Research progress on the relationship between myasthenia gravis and diaphragm
投稿时间:2024-05-30  修订日期:2024-05-30
DOI:
中文关键词: 重症肌无力  膈肌  呼吸功能  综述
英文关键词: Research progress on the relationship between myasthenia gravis and diaphragm
基金项目:
作者单位邮编
张燕迪 北京大学人民医院神经内科 100044
贺超 北京大学人民医院神经内科雄安宣武医院神经内科 
毛春燕 北京大学人民医院神经内科 
朱利娜 北京大学人民医院神经内科 
袁远 北京,北京大学人民医院神经内科 100044
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中文摘要:
      大约15~20%重症肌无力(MG)患者在病程的前2~3年发生肌无力危象[1],由于累及呼吸肌,而出现咳嗽无力、呼吸困难,不能维持正常通气功能,必须用呼吸机辅助呼吸。早期评估MG患者呼吸肌功能可以为发生肌无力危象风险判断提供依据。膈肌作为人体主要的呼吸肌,将胸腔和腹腔分开,与呼吸功能密不可分,但以往有关膈肌功能研究的文献尚缺乏有效整合。本文将从重症肌无力抗体影响因素、临床分型、发生膈肌功能障碍的机制、表现、检查、诊断方法等方面进行归纳综述,从而为MG患者呼吸功能的深入研究和临床应用提供一定的参考。
英文摘要:
      Myasthenic crisis occurs in approximately 15%–20% of patients with MG usually within the first 2 to 3 y of the disease course[1], which involves respiratory muscles, resulting in cough weakness and dyspnea, which cannot maintain normal ventilation function and must be assisted by ventilators [1]. Early assessment of respiratory muscle function in MG patients can provide evidence for the risk of myasthenic crisis. The diaphragm, as the main respiratory muscle, separates the chest cavity from the abdominal cavity and is closely related to respiratory function. However, the literature on the function of the diaphragm has not been effectively integrated in the past. This article will summarize the influencing factors of myasthenia gravis antibody, clinical classification, mechanism, manifestation, examination and diagnosis methods of diaphragmatic dysfunction, so as to provide a certain reference for further research and clinical application of respiratory function in MG patients.
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