| Abstract Objective: To investigate the current status and influencing factors of sarcopenia in patients with Diabetic Peripheral Neuropathy (DPN). Methods: Convenience sampling was used to select 202 DPN patients admitted to a tertiary hospital in Hubei Province from February to October 2023. Patients completed surveys including a general information questionnaire, PHQ-9, Charlson Comorbidity Index, and PSQI. Patients were categorized into sarcopenia and non-sarcopenia groups based on 2019 diagnostic criteria by the Asian Working Group for Sarcopenia, to analyze sarcopenia occurrence and influencing factors. Results: Among 202 DPN patients, 39 were diagnosed with sarcopenia, including 7 males (17.94%) and 32 females (82.06%), with a sarcopenia incidence rate of 19.31%. Significant differences (P＜0.05) were observed in gender, age, waist circumference, BMI, duration of physical exercise, osteoporosis,PHQ-9 score, CCI index, PSQI score, vitamin D levels, total cholesterol, red blood cell count, and creatinine. Logistic regression analysis results indicated that Deficiency in 25-hydroxyvitamin D, high PHQ-9 scores, decreased waist circumference, high PSQI scores, and low red blood cell count are risk factors for sarcopenia in DPN patients (P＜0.05). Conclusion: The sarcopenia rate is high in DPN patients. Healthcare providers should promptly identify high-risk populations and intervene to prevent or delay sarcopenia and its adverse health consequences. |