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| 额颞叶痴呆体液标志物研究进展 |
| Advances in fluid biomarkers of frontotemporal dementia |
| 投稿时间：2024-04-16 修订日期：2024-04-16 |
| DOI： |
| 中文关键词: 额颞叶痴呆 体液标志物 早期诊断 综述 |
| 英文关键词: Frontotemporal dementia Biomarkers Early diagnosis Review |
| 基金项目:北京市自然科学基金面上项目：疾病相关小胶质细胞亚型在1型糖尿病认知功能障碍中的作用及机制研究 No.7222064 |
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| 中文摘要: |
| 额颞叶痴呆是常见的神经变性病和早发型痴呆,突出表现为精神行为异常和认知障碍,由于发病机制不清、异质性突出,目前早期诊断和治疗困难。近年来由于技术不断成熟,额颞叶痴呆体液标志物相关研究成为热点,有较多研究已经发现了一些有潜在应用价值的标志物分子。因此,本文特将近期相关研究归纳总结,以期临床医生能够了解额颞叶痴呆早期诊断标志物的研究进展,希望能为后续的基础研究提供参考方向,为临床应用提供可能选择。 |
| 英文摘要: |
| Frontotemporal dementia (FTD) is a common neurodegenerative disease and early-onset dementia, which is characterized by mental and behavioral abnormalities and cognitive impairment. On account of the unclear pathogenesis and prominent heterogeneity of the disease, the early diagnosis and treatment are difficult at present. In recent years, the research on fluid biomarkers of FTD has become a hot spot owe to the continuous maturity of technical means, and many studies have found some biomarker molecules with potential application value. Therefore, we summarize the recent related literatures and hope that the clinicians will understand the current research progress of early diagnostic biomarkers of FTD. Moreover, we look forward to providing a reference direction for subsequent basic research and a possible choice for clinical application in the future. |
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