文章摘要
小胶质细胞极化在蛛网膜下腔出血早期脑损伤中的作用机制研究进展
Research Progress on the Role of Microglia Polarization in Early Brain Injury after Subarachnoid Hemorrhage
投稿时间:2024-03-20  修订日期:2024-03-20
DOI:
中文关键词: 蛛网膜下腔出血  早期脑损伤  小胶质细胞  神经炎症
英文关键词: subarachnoid hemorrhage  early brain injury  microglia  neuroinflammation
基金项目:山西省科学技术厅自然科学面上项目(2021030212364);山西省卫生健康委员会科研课题(2019045)
作者单位邮编
张一博 山西医科大学 030001
孙新刚 山西医科大学第二医院神经内科 030000
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中文摘要:
      蛛网膜下腔出血(SAH)是神经系统的急危重症,常有不良预后。临床研究发现早期脑损伤(EBI)广泛存在于SAH患者中,可能是造成预后不良的重要原因。临床前研究在了解EBI的机制方面取得了进展,小胶质细胞是参与EBI的主要细胞成分。EBI中的神经炎症主要由M1型小胶质细胞驱动,参与血脑屏障破坏和神经元死亡;此外,M2表型小胶质细胞表现出减轻脑水肿和改善神经功损伤的功能。因此,阐明SAH后小胶质细胞的极化及参与EBI的途径对干预SAH神经炎症反应具有重要意义。
英文摘要:
      Subarachnoid hemorrhage (SAH) is a neurological emergency and often carries a poor prognosis. Clinical studies have found that early brain injury (EBI) is widespread in patients with SAH and may be an important cause of poor prognosis. Preclinical studies have made progress in understanding the mechanisms of EBI, and microglia are the major cellular components involved in EBI. Neuroinflammation in EBI is mainly driven by M1 phenotype microglia, which are involved in blood-brain barrier disruption and neuronal death; in addition, M2 phenotype microglia exhibit functions in reducing cerebral edema and ameliorating neurological work injury. Therefore, elucidating the polarization in microglia and the pathways affecting EBI after SAH is important for its intervention in the neuroinflammatory response to SAH.
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