文章摘要
全身免疫炎症指数与急性脑梗死患者静脉溶栓后早期神经功能恶化的相关性研究
Correlation between systemic immune inflammatory index and early neurological deterioration after intravenous thrombolysis in patients with acute cerebral infarction
投稿时间:2024-03-17  修订日期:2024-03-17
DOI:
中文关键词: 急性脑梗死  早期神经功能恶化  全身免疫炎症指数  
英文关键词: acute cerebral infarction  Early neurological deterioration  systemic immune inflammation index  
基金项目:
作者单位邮编
马莉 安徽医科大学第二附属医院 230000
吴凡 安徽医科大学第二附属医院 
方传勤 安徽医科大学第二附属医院 230000
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中文摘要:
      目的 探讨全身免疫炎症指数(systemic immune inflammation index, SII)与阿替普酶静脉溶栓的急性脑梗死(acute cerebral infarction,ACI)患者早期神经功能恶化(early neurological deterioration,END)的相关性。方法 收集安徽医科大学第二附属医院神经内科2019.6到2023.06共228例发病4.5h内接受标准剂量阿替普酶静脉溶栓治疗的急性脑梗死患者的所有基线资料。根据是否出现END分为END组和非END组。对两组间资料进行单因素数据分析,筛选出与END有关的危险因素将其引入二元logistic回归分析模型中进一步分析;采用受试者工作特征(ROC)曲线评估SII指数对静脉溶栓的急性脑梗死患者发生END的预测价值。结果 纳入的228例急性脑梗死患者中43例(18.9%)发生END,二元logistic回归分析显示,溶栓前NIHSS评分、SII是发生END的独立危险因素(P<0.05),ROC曲线分析显示SII预测END的曲线下面积为0.717(95%CI:0.617~0.817),最佳截断值为627.12×109/L,灵敏度和特异度分别为55.8%和84.3%。结论 溶栓前高SII与静脉溶栓患者发生END相关,可在一定程度上预测阿替普酶静脉溶栓患者的早期神经功能恶化。
英文摘要:
      To investigate the correlation between systemic immune inflammatory index ( SII ) and early neurological deterioration ( END ) in patients with acute cerebral infarction ( ACI ) treated with intravenous thrombolysis with alteplase. Methods All baseline data of 228 patients with acute cerebral infarction who received standard-dose alteplase intravenous thrombolysis within 4.5 hours of onset from 2019.06 to 2023.06 in the Department of Neurology, the Second Affiliated Hospital of Anhui Medical University were collected. According to the presence or absence of END, they were divided into END group and non-END group. Univariate data analysis was performed on the data between the two groups, and the risk factors related to END were selected and introduced into the binary logistic regression analysis model for further analysis. The receiver operating characteristic ( ROC ) curve was used to evaluate the predictive value of SII index for END in patients with acute cerebral infarction undergoing intravenous thrombolysis. Results Among the 228 patients with acute cerebral infarction, 43 ( 18.9 % ) had END. Binary logistic regression analysis showed that NIHSS score and SII before thrombolysis were independent risk factors for END ( P < 0.05 ). ROC curve analysis showed that the area under the curve of SII predicting END was 0.717 ( 95 % CI : 0.617-0.817 ), the optimal cut-off value was 627.12 × 109 / L, the sensitivity and specificity were 55.8 % and 84.3 %, respectively. Conclusion High SII before thrombolysis is associated with END in patients with intravenous thrombolysis, which can predict the early neurological deterioration of patients with intravenous thrombolysis with alteplase to a certain extent.
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