文章摘要
小胶质细胞TREM2在阿尔茨海默病发病机制中作用的研究进展
Advances in the roles of TREM2 in microglia in the pathogenesis of Alzheimer disease
投稿时间:2023-10-27  修订日期:2023-10-27
DOI:
中文关键词: 阿尔茨海默病  小胶质细胞  髓系细胞触发受体2
英文关键词: Alzheimer's disease  Microglia  Triggering receptor expressed on myeloid cells 2
基金项目:北京市自然科学基金(7222064, 7232003);国家自然科学基金(82071539)
作者单位邮编
刘益萌 首都医科大学附属北京安定医院 100088
赵丽 首都医科大学基础医学院 
王玥 首都医科大学附属北京安定医院 100088
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中文摘要:
      阿尔茨海默病(Alzheimer"s disease, AD)常见于老年人,临床表现为记忆力减退、精神行为异常等。AD的发病机制目前尚不清楚,目前存在的多种假说并不能完全解释AD的全部发病特征。小胶质细胞是脑组织中特殊的巨噬细胞,可监测周围神经元和胶质细胞的健康情况,同时具有神经保护和神经毒性作用。近年来通过对AD的不断深入研究发现,小胶质细胞通过髓系细胞触发受体2(triggering receptor expressed on myeloid cells 2, TREM2)参与AD发病机制,TREM2功能丧失会加剧AD的发展进程。本文就TREM2及其突变体介导小胶质细胞功能改变在AD发生发展中的作用进行综述。
英文摘要:
      Alzheimer’s disease (AD) is common in the elderly and its clinical manifestations are characterized by memory loss, mental and behavioral abnormalities and so on. At present, the pathogenesis of AD remains unclear. Several hypotheses do not fully explain the characteristics of clinical features of AD. Microglia are the resident brain macrophages that monitor the health of surrounding neurons and glial cells. Microglia have both neuroprotective and neurotoxic effects. In recent years, continuous in-depth researches on AD found that microglia participate in the pathogenesis of AD via triggering receptor expressed on myeloid cells 2 (TREM2). The loss of TREM2 function will facilitate the development of AD. This review focused on the role of TREM2 and its mutants in the genesis and progression of AD.
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