文章摘要
睡眠-觉醒节律紊乱与阿尔茨海默病
Sleep-Wake Cycle Disturbances And Alzheimer's Disease
投稿时间:2023-10-24  修订日期:2023-10-24
DOI:
中文关键词: 阿尔茨海默病  睡眠-觉醒节律紊乱  β淀粉样蛋白  tau蛋白  神经炎症  氧化应激
英文关键词: Alzheimer"s disease  Sleep-Wake Cycle Disturbances  Amyloid-β-Protein  tau protein  Neuroinflammation  Oxidative Stress.
基金项目:
作者单位邮编
姚宇 南京医科大学鼓楼临床医学院 210008
李墅明 南京大学医学院附属鼓楼医院麻醉科 
刘欢 南京大学医学院附属鼓楼医院麻醉科 
顾小萍 南京医科大学鼓楼临床医学院 210008
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中文摘要:
      阿尔茨海默病(Alzheimer’s disease,AD)是一种最常见的神经退行性疾病,主要临床表现为损伤性的、不可逆转的认知功能障碍。睡眠-觉醒节律紊乱是AD患者的常见症状,然而大量研究表明早在AD行为症状发生之前睡眠-觉醒节律紊乱已经存在。正常的睡眠-觉醒节律有利于β淀粉样蛋白(Amyloid-β-protein, Aβ)和tau蛋白的排泄。然而,当睡眠-觉醒周期被打乱,中枢神经系统(central nervous system,CNS)对有害代谢物的清除就会减少。此外,睡眠-觉醒节律紊乱也可导致神经炎症和CNS氧化应激的产生,加速认知的损害。因此,本综述主要探讨睡眠-觉醒节律紊乱与AD发生发展的关系。
英文摘要:
      Alzheimer"s disease (AD) is the most common neurodegenerative disease, characterized by detrimental and irreversible cognitive impairment. Sleep-wake rhythm disturbances are common symptoms in AD patients, and numerous studies have shown that sleep-wake rhythm disturbances exist even before the onset of AD behavioral symptoms. The normal sleep-wake rhythm facilitates the clearance of Amyloid-β-protein(Aβ) and tau protein. However, when the sleep-wake cycle is disrupted, the central nervous system(CNS) reduces its clearance of harmful metabolites. Furthermore, sleep-wake rhythm disturbances can also lead to neuroinflammation and CNS oxidative stress, accelerating cognitive damage. Therefore, this review primarily explores the relationship between sleep-wake rhythm disturbances and the occurrence and progression of AD.
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