Objective: To investigate the effects of obstructive sleep apnea syndrome (OSAS) of different degrees on the stability of vascular plaque in patients with cerebral infarction, and the effects of OSAS of different degrees on the volume of white matter hyperintensity (WMH) in patients with cerebral infarction. Methods: According to the inclusion and exclusion criteria, 79 patients with cerebral infarction were retrospectively collected. OSAS patients with cerebral infarction were diagnosed by standard polysomnography (PSG), and the patients were divided into mild OSAS group (AHI: 5-15) and moderate severe OSAS group (AHI: ≥15) according to the Apnea Hypopnea Index (AHI). High resolution Magnetic Resonance Imaging (HR-MRI) was used to detect the intracranial and extracranial plaques of the patient, and on the 3D T1 SPACE plane, RadiAnt DICOM Viewer 2.3 (64 bit) software was used to manually measure the plaque length, total vessel area (TVA), lumen area (LA), wall area (WA) The normalized wall index (NWI), remodeling index, TVA of adjacent normal blood vessels and other plaque characteristics were used to divide WMH into total white matter hyperintensity (TWMH), periventricular white matter hyperintensity (PVWMH) and deep white matter hyperintensity (DWMH), and automatically calculate the patient's TWMH volume PVWMH volume, DWMH volume, and finally use statistical software to conduct statistical analysis on the data. Results: 1. Comparing the traditional vascular influencing factors between the two groups, we found that there was a statistical difference in the history of hypertension between the two groups (37% vs 62%, P<0. 038); There were significant differences in plaque load, remodeling index, plaque length and other plaque characteristics between the two groups (P; The TWMH volume and PVWMH volume between the two groups were statistically different (P<0.05). Conclusion: Moderate and severe OSAS can aggravate the instability of plaque in patients with cerebral infarction; In patients with cerebral infarction, the volume of TWMH and PVWMH will increase with the severity of OSAS. |