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| 表观遗传调控在与阿尔茨海默病相关认知功能障碍中的作用 |
| The Role of Epigenetic Regulation in Cognitive DysfunctionAssociated with Alzheimer"s Disease |
| 投稿时间：2023-03-14 修订日期：2023-03-14 |
| DOI： |
| 中文关键词: 认知功能障碍 阿尔茨海默病(AD) 表观遗传调控 组蛋白修饰 DNA甲基化 非编码RNA调控 |
| 英文关键词: cognitive dysfunction Alzheimer’s disease(AD) epigenetic regulation histone modification DNA methylation non-coding RNA regulation |
| 基金项目:2019年国家自然科学基金地区科学(81960211),组蛋白乙酰化-miRNA(miR-671/miR-483-5p)环路调控海马神经元树突棘重塑在孕晚期母体接受丙泊酚麻醉手术致子代大鼠学习记忆损害中的作用,受资助者：罗佛全 |
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| 中文摘要: |
| 认知功能障碍是常见的神经精神类病症，常见于中枢神经系统退行性疾病、严重创伤及手术后患者，机制复杂。表观遗传学是一种不同于遗传学的基因表达调控的遗传性变化，其可以通过调控众多基因谱的表达，参与诸多生理功能的调控。越来越多证据提示，表观遗传调控在正常认知功能的形成与维持中起重要作用。表观遗传主要调控机制如组蛋白修饰、DNA甲基化、非编码RNA调控等障碍与认知功能障碍的发生有关，纠正这些障碍的表观遗传调控机制对认知功能障碍有一定缓解作用。不同表观遗传调控机制之间存在密切联系，它们之间相互作用共同调节认知功能。该研究以常见的中枢神经系统疾病阿尔茨海默病（AD）为重点，总结分析表观遗传调控机制在AD相关认知功能障碍中的作用，有助于阐明AD相关认知功能障碍的表观遗传调控病理机制，并可为其防治提供新思路。 |
| 英文摘要: |
| Cognitive dysfunction is a common neuropsychiatric disorder, commonly seen in patients with degenerative diseases of the central nervous system, severe trauma and post-surgery, with complex mechanisms. Epigenetics is a genetic variation in the regulation of gene expression that differs from genetics in that it can be involved in the regulation of many physiological functions by regulating the expression of numerous gene profiles. Increasing evidence suggests that epigenetic regulation plays an important role in the formation and maintenance of normal cognitive function. Disorders of major epigenetic regulatory mechanisms such as histone modification, DNA methylation, and non-coding RNA regulation are associated with the development of cognitive dysfunction, and that correcting the epigenetic regulatory mechanisms of these disorders has a mitigating effect on cognitive dysfunction. There are close links between different epigenetic regulatory mechanisms, which interact to regulate cognitive function. This study focuses on Alzheimer's disease (AD), a common central nervous system disorder, and summarizes and analyzes the role of epigenetic regulatory mechanisms in AD-related cognitive dysfunction, which can help to elucidate the epigenetic regulatory pathogenesis of AD-related cognitive dysfunction and provide new ideas for its prevention and treatment. |
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