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| 原发性进行性冻结步态3例报道并文献复习 |
| Primary Progressive Freezing Gait: Report of Three Cases with Review of Literature |
| 投稿时间：2022-07-20 修订日期：2022-07-20 |
| DOI： |
| 中文关键词: 原发性进行性冻结步态 临床特点 帕金森病 病例报道 |
| 英文关键词: Primary progressive freezing gait Clinical features Parkinson's disease Case report |
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| 中文摘要: |
| 目的:回顾3例原发性进行性冻结步态（Primary Progressive Freezing Gait，PPFG）患者的临床资料，加深对该病的认识。方法:总结并分析3例首诊考虑帕金森病（Parkinson’s Disease，PD），应用多巴胺能药物治疗效果不佳，后拟诊PPFG患者的临床资料，并进行文献复习，来探讨PPFG的发病机制。结果:3例患者符合PPFG诊断，多巴胺能药物治疗效果较差，应用司来吉兰疗效较好。PPFG的起病，存在多种途径。结论:PPFG是一类神经系统退行性疾病，单胺氧化酶B抑制剂与多巴胺类药物相比，有更为显著、持续的疗效。PPFG与PD发病机制存在明显区别。 |
| 英文摘要: |
| objective:The clinical data of three patients with Primary Progressive Freezing Gait (PPFG) were reviewed to further understand the disease. Methods:The clinical data of three patients with PPFG who were first diagnosed with Parkinson's Disease (PD) and had poor therapeutic effects of dopaminergic drugs were summarized and analyzed, and the pathogenesis of PPFG was discussed through literature review. Results:Three patients were diagnosed with PPFG, and the effect of dopaminergic drugs was poor, while selegiline was better. There are many pathways to the onset of PPFG. Conclusion:PPFG is a class of neurodegenerative diseases, and monoamine oxidase B inhibitors have more significant and sustained efficacy compared with dopamine drugs. The pathogenesis of PPFG and PD is obviously different |
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