文章摘要
自发性脑出血后抑郁的研究进展
Research progress of depression after Spontaneous intracerebral hemorrhage
投稿时间:2022-05-30  修订日期:2022-05-30
DOI:
中文关键词: 脑出血  抑郁  发病机制  治疗
英文关键词: Intracerebral hemorrhage  Depression  Pathogenesis  Treatment
基金项目:
作者单位E-mail
范彩霞 贵州医科大学 1406729916@qq.com 
蔡胤浩 贵州医科大学  
伍国锋 贵州医科大学 wuguofeng3013@sina.com 
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中文摘要:
      自发性脑出血(Spontaneous intracerebral hemorrhage, sICH)是一种常见的卒中亚型,具有致残率高和死亡率高的特点,并且经常合并多种并发症。抑郁症患者的大脑结构变化与神经系统的某些部分密切相关,脑容量减少与抑郁发作有关。卒中后抑郁(Post-stroke depression,PSD)是卒中患者最常见的精神并发症,对幸存者的功能结果、对康复的反应和生活质量产生负面影响。相比于缺血性卒中,sICH的PSD患病率明显偏高。在sICH幸存者中,与非抑郁患者相比,PSD与发病后6个月内神经功能恶化之间存在显著关联,神经功能恶化的患者的抑郁得分更高。目前国内外关于sICH后抑郁的研究相对较少。本文通过对sICH后抑郁的影响因素、发病机制、治疗方式等进行综述,以期为sICH后抑郁的干预及预后提供理论基础。
英文摘要:
      Spontaneuos intracerebral hemorrhage (sICH) is a common subtype of stroke, which is characterized by high disability and mortality, and is often associated with a variety of complications. Post-stroke depression (PSD) is the most common mental complication in patients with sICH, which has a negative impact on the functional outcome, rehabilitation response and quality of life of survivors. Compared with ischemic stroke, the prevalence of PSD in sICH is significantly higher. Among sICH survivors, there was a significant association between PSD and neurological worsening within 6 months of onset compared with non-depressed patients, with higher depression scores in patients with worsening neurological function. At present, there are relatively few studies on post-ICH depression. This article reviews the influencing factors, pathogenesis and treatment of post-ICH depression, in order to provide a theoretical basis for the intervention and prognosis of post-ICH depression.
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