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5-HT递质系统与帕金森病非运动症状的关系及治疗的研究 |
Study on the relationship between 5-HT transmitter system and non-motor symptoms of Parkinson |
投稿时间:2022-03-23 修订日期:2022-03-23 |
DOI: |
中文关键词: 帕金森病 5-HT 非运动症状 |
英文关键词: Parkinson's disease 5-HT non-motor symptoms |
基金项目:国家自然科学基金(81241037);通讯作者:王天俊,E-mail: wangtianj2007@126.com; |
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中文摘要: |
目前较多研究已揭示帕金森病(PD)运动症状的病理生理机制及治疗,然而针对其非运动症状(NMS)的形成机制及用药较有限,并且多数患者在确诊前早已出现未受关注的NMS,进一步证明尽早诊断PD及探索新型药物治疗PD-NMS的必要性。近年来,国内外研究发现五羟色胺(5-HT)与PD-NMS及治疗用药之间存在密切联系。本文就目前常见的NMS与5-HT之间的关系及治疗用药进行综述,旨为临床诊治PD-NMS提供新思路。 |
英文摘要: |
At present, many studies have revealed the pathophysiological mechanism and treatment of motor symptoms in Parkinson"s disease (PD). However, the formation mechanism and medication of non-motor symptoms (NMS) are limited, and most patients have already appeared unconcerned NMS before diagnosis, which further proves the necessity of early diagnosis of PD and exploration of new drug therapy for PD-NMSSIn recent years, domestic and foreign studies have found that there is a close relationship between 5-ht and PD-NMS as well as its therapeutic agents. This article reviews the relationship between 5-HT and PD-NMS as well as its therapeutic agents, aiming to provide new ideas for clinical diagnosis and treatment of PD-NMS |
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