| 任凯夕，赵代弟，白苗，卢佳睿，李宏增，郭俊.外周血单核细胞及其亚群数量在吉兰-巴雷综合征病程中的变化及临床意义[J].神经损伤功能重建,2022,17(知网首发): |
| 外周血单核细胞及其亚群数量在吉兰-巴雷综合征病程中的变化及临床意义 |
| Changes and Clinical Significance of Peripheral Blood Monocytes and Their Subpopulations inVarious Phases of Guillain-Barré Syndrome |
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| DOI： |
| 中文关键词: 吉兰-巴雷综合征 典型单核细胞 非典型单核细胞 MRC总和评分 |
| 英文关键词: Guillain-Barré syndrome classical monocyte non-classical monocyte MRC sum score |
| 基金项目:国家自然科学基金
（No. 82171339） |
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| 中文摘要: |
| 目的：分析吉兰-巴雷综合征（GBS）患者的外周血单核细胞及其亚群数量在病程不同阶段的变化规律
及其临床意义。方法：收集118例GBS首次发病患者，给予正规GBS治疗并随访18个月，根据随访期GBS
的复发及再次入院治疗情况，最终分组为急性期组 118 例，缓解期组 36 例，复发期组 6 例次；健康志愿者
96例纳入对照组。每次入院时，均进行休斯功能分级量表评分（HFGS）及医学研究理事会总和评分（MRC）
评分；采集外周血进行血常规检验及流式细胞术分析；分析各组外周血单核细胞亚群变化及其与MRC总和
评分相关性。结果：急性期组及复发期组单核细胞计数高于对照组（均P＜0.05）。急性期组和复发期组外
周血经典型单核细胞（c-Mo）较其他2组明显增加（均P＜0.05）；对照组和缓解期组，外周血非经典型单核细
胞（n-Mo）较其他 2 组明显增加（均 P＜0.05）。在急性期组，c-Mo 数量与 MRC 总和评分呈负相关（P＜ 0.05）。结论：外周血单核细胞及其亚群在GBS病程不同阶段具有特征性的变化，其中c-Mo升高与疾病严
重程度呈正相关性。 |
| 英文摘要: |
| To analyze the changes and clinical significance of peripheral blood monocytes and their
subpopulations in various phases of Guillain-Barré syndrome (GBS). Methods: One hundred eighteen first
onset GBS patients were recruited who were treated regularly and followed up for 18 months. Based on the
recurrence of GBS and the readmission to the hospital during the follow-up period, patients were eventually
divided into acute-onset GBS (a-GBS) group (n=118), GBS in remission (rem-GBS) group (n=36) and recurrent
GBS (rec-GBS) group (n=6). Ninety-six healthy volunteers were included in the control group. Hughes
Functional Grading Scale (HFGS) and Medical Research Council (MRC) were performed at each admission.
Peripheral blood was collected for routine blood examination and flow cytometry analysis. The changes of
peripheral blood monocyte subpopulations and their correlation with MRC summation score were analyzed.
Results: Monocytes counts in a-GBS group and rem-GBS group were higher than those in control group (P< 0.05). Classical monocyte (c-Mo) in a-GBS group and rem-GBS group were higher than those in control group
and rec-GBS group (P<0.05). Non-classical monocyte (n-Mo) in control group and rec-GBS group were higher
than those in a-GBS group and rem-GBS group (P<0.05). The counts of c-Mo were negatively correlated to the
MRC sum score in a-GBS group (P<0.05). Conclusion: There were certain variation patterns of peripheral
blood monocytes and their sub-populations in various phased of GBS. The increase of c-Mo was positively
correlated with the severity of GBS. |
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