| 陈芳
，温春丽
，胡风云.光污染与癫痫及生物节律的交叉影响机制研究[J].神经损伤功能重建,2025,(知网首发): |
| 光污染与癫痫及生物节律的交叉影响机制研究 |
| Research on the Cross-Impact Mechanism of Light Pollution with Epilepsy and BiologicalRhythm |
| |
| DOI： |
| 中文关键词: 光污染 光敏性癫痫 生物节律 褪黑素 神经兴奋性 |
| 英文关键词: light pollution photosensitive epilepsy circadian rhythm melatonin neuronal hyperexcitability |
| 基金项目:山西省重点研发计
划（指南）项目（心
脑血管疾病发病机
制研究与治疗-重
症脑卒中血清标志
物与临床预后的相
关性研究，No. 201
603D321060）；吴
阶平医学基金会临
床科研专项资助基
金（注射用丹参多
酚酸对斑块稳定性
及血管新生作用的
临床研究，No. 320.
6750.16129） |
|
| 摘要点击次数: 30 |
| 全文下载次数: 47 |
| 中文摘要: |
| 光污染对神经系统的潜在影响日益引起关注，已成为神经科学新兴研究领域。本综述系统性探讨了光
污染与光敏性癫痫（photosensitive epilepsy，PSE）的复杂关联机制。研究发现，光污染尤其是蓝光（480 nm）
通过视网膜非成像细胞（ipRGCs）直接抑制褪黑素分泌，并间接破坏生物节律，显著增加癫痫发作风险。关
键机制包括：神经元兴奋性异常升高、生物钟基因表达紊乱，以及通过氧化应激和神经炎症加剧癫痫病理进
程。干预策略涵盖时间疗法、褪黑素补充和公共卫生措施。未来研究应聚焦多学科交叉、新技术应用，开发
基于个体化的精准预防与治疗策略，为缓解光污染对神经系统的潜在危害提供科学依据。 |
| 英文摘要: |
| The potential impact of light pollution on the nervous system is attracting increasing attention and has
become a new research field in neuroscience. This review systematically explores the complex interaction mechanisms between light pollution and photosensitive epilepsy (PSE). Evidence indicates that light pollution, especially blue light exposure at 480 nm, significantly elevates seizure susceptibility through two principal pathways: primarily through direct suppression of melatonin secretion via intrinsically photosensitive retinal ganglion cells
(ipRGCs) and secondary disruption of circadian rhythms. Core mechanisms involve three pathological dimensions: abnormal elevation of neuronal excitability, dysregulation of circadian clock gene expression patterns, and
exacerbation of epileptogenic processes through oxidative stress and neuroinflammatory pathways. Current intervention strategies encompass chronotherapeutic approaches, melatonin supplementation protocols, and public
health policy initiatives. Future research should focus on interdisciplinary integration and the application of new
technologies to develop personalized precision prevention and treatment strategies, providing a scientific basis
for mitigating the potential harm of light pollution on the nervous system. |
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