| 邢可斌
，裴飞
，王虹焱
，王艳.自主神经系与成骨细胞-破骨细胞通讯研究进展[J].神经损伤功能重建,2025,(知网首发): |
| 自主神经系与成骨细胞-破骨细胞通讯研究进展 |
| Research Progress on the Autonomic Nervous System and Osteoblast-Osteoclast Communication |
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| DOI： |
| 中文关键词: 去甲肾上腺素 乙酰胆碱 成骨细胞 破骨细胞 |
| 英文关键词: norepinephrine acetylcholine osteoblasts osteoclasts |
| 基金项目: |
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| 摘要点击次数: 36 |
| 全文下载次数: 55 |
| 中文摘要: |
| 骨是具有高度动态和适应性的组织，它经历不断的重塑以生长、愈合损伤并调节钙和磷代谢。在维持
骨稳态的过程中，起关键作用的是具有促成骨功能的成骨细胞和具备骨降解功能的破骨细胞，二者功能失
调会导致骨稳态失衡。自主神经系统作为中枢神经与骨骼系统之间的核心调控桥梁，对维持骨稳态具有
不可替代的生理意义。本文对近年关于成骨细胞-破骨细胞通讯以及自主神经系统参与骨吸收与骨重塑调
控作用的相关研究进行综述，结果显示，自主神经系统可通过分泌去甲肾上腺素和乙酰胆碱等神经递质，激
活细胞上相关肾上腺素能受体和乙酰胆碱能受体，调控PER1、PER2、Bmal 1、RUNX2和OPN等相关基因及
cAMP/PKA/CREB、Wnt/β-catenin等相关信号通路，进而影响成骨细胞和破骨细胞，调节骨重建过程中的多种
生理活动。 |
| 英文摘要: |
| Bones are highly dynamic and adaptive tissues that undergo continuous remodeling for growth, healing
of injuries, and regulation of calcium and phosphorus metabolism. In the maintenance of bone homeostasis, osteoblasts with bone-forming functions and osteoclasts with bone-resorbing functions play crucial roles. Dysfunction
of these two types of cells can lead to a disruption of bone homeostasis. The autonomic nervous system, as a core
regulatory bridge between the central nervous system and the skeletal system, has an irreplaceable physiological
significance in maintaining bone homeostasis. This article reviews recent studies on osteoblast-osteoclast communication and the role of the autonomic nervous system in the regulation of bone resorption and remodeling. The results show that the autonomic nervous system can secrete neurotransmitters such as norepinephrine and acetylcholine, activate adrenergic and cholinergic receptors on cells, regulate related genes such as PER1, PER2, Bmal1,
RUNX2, and OPN, as well as signaling pathways like cAMP/PKA/CREB and Wnt/β-catenin, thereby affecting osteoblasts and osteoclasts and modulating various physiological activities during bone reconstruction. |
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