| 王晓莉
，杨柳,
，韩冠先,.微环境因素调控多发性硬化髓鞘再生的作用及机制研究进展[J].神经损伤功能重建,2024,(知网首发): |
| 微环境因素调控多发性硬化髓鞘再生的作用及机制研究进展 |
| Research Progress on the Role and Mechanism of Microenvironmental Factors in RegulatingRemyelination in Multiple Sclerosis |
| |
| DOI： |
| 中文关键词: 多发性硬化 髓鞘再生 少突胶质前体细胞 微环境 小胶质细胞 |
| 英文关键词: multiple sclerosis remyelination oligodendrocyte precursor cells microenvironment microglia |
| 基金项目:河南省医学科技攻
关计划联合共建项
目（基于网络药理
学和代谢组学探讨
三七愈凤胶囊干预
急性缺血脑卒中的
潜在机制，No. LH
GJ20230833）；国
家中医药管理局全
国名老中医药专家
传承工作室建设项
目（第七批继承工
作，No. 国中医药人
教函[2022]76号） |
|
| 摘要点击次数: 177 |
| 全文下载次数: 437 |
| 中文摘要: |
| 多发性硬化（multiple sclerosis，MS）病理机制复杂，目前的临床治疗措施并不能阻止病情进展且副作
用较多，急需开发新的有效临床治疗措施以改善MS患者临床症状和预后。髓鞘再生可以为MS整个病程
提供益处，促进髓鞘再生是一种极具潜力的MS治疗措施。少突胶质前体细胞作为负责MS髓鞘再生的细
胞，其髓鞘再生能力受多种微环境因素的影响。本文首次综述固有免疫细胞、髓鞘碎片、细胞外基质、星形
胶质细胞、神经元、周细胞和内皮细胞、适应性免疫细胞、外周循环和衰老等微环境因素对MS髓鞘再生的
影响和机制，以期为MS的防治提供参考。 |
| 英文摘要: |
| Multiple sclerosis (MS) pathogenesis is complex, and current clinical treatments cannot halt disease
progression and have numerous side effects. There is an urgent need to develop new and effective clinical
treatments to improve the clinical symptoms and prognosis of MS patients. Remyelination can provide benefits
throughout the entire course of MS, making it a highly promising treatment approach for MS. Oligodendrocyte
precursor cells, responsible for myelin regeneration in MS, have their regenerative capacity influenced by
various microenvironmental factors. This article provides the first review of the impact and mechanisms of
microenvironmental factors such as innate immune cells, myelin debris, extracellular matrix, astrocytes,
neurons, pericytes and endothelial cells, adaptive immune cells, peripheral circulation, and aging on MS
remyelination, aiming to offer references for the prevention and treatment of MS. |
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