| 苗晨欣
，李晓宁.微小RNA在抑郁症中的研究进展[J].神经损伤功能重建,2024,(知网首发): |
| 微小RNA在抑郁症中的研究进展 |
| Progress of MicroRNA Research in Depression |
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| DOI： |
| 中文关键词: 微小RNA 抑郁症 表观遗传学 综述 |
| 英文关键词: microRNA depression epigenetics review |
| 基金项目: |
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| 摘要点击次数: 577 |
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| 中文摘要: |
| 抑郁症是最常见的一种情感性精神障碍，全球大约有超过4亿人患有抑郁症。抑郁症的早期预测和
有效的治疗对疾病预后至关重要。微小RNA（microRNA，miRNA）作为研究最为广泛的非编码RNA，参与
抑郁症发病相关的多种机制，被认为是抑郁症的潜在生物标志物。本文总结了miRNA在多种抑郁类型中
作为早期诊断以及潜在治疗靶点的研究，揭示了miRNA在抑郁症中的潜在临床意义，并提出对于目前研
究现状的思考，以期为抗抑郁治疗提供参考。 |
| 英文摘要: |
| Depression is one of the most common affective mental disorders, with over 400 million people
worldwide suffering from depression. Early prediction and effective treatment of depression are crucial for the
prognosis of the disease. MicroRNAs (miRNAs), being the most widely studied class of non-coding RNAs, are
involved in various mechanisms related to the pathogenesis of depression and are considered potential
biomarkers for the condition. This article summarizes research on the role of miRNAs as early diagnostic
markers and potential therapeutic targets across different types of depression, revealing their potential clinical
significance in depression. It also presents reflections on the current state of research, aiming to provide
references for antidepressant therapy. |
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