| 罗川瑞,
，吕靖,
，周惠,
，张媛,
，张冯,
，罗向红,.星形胶质细胞在睡眠剥夺中的作用及其机制[J].神经损伤功能重建,2025,(知网首发): |
| 星形胶质细胞在睡眠剥夺中的作用及其机制 |
| Research on the Role and Mechanisms of Astrocyte Activation in Sleep Deprivation |
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| DOI： |
| 中文关键词: 睡眠剥夺 星形胶质细胞 A1/A2反应性星形胶质细胞 认知功能障碍 活化 |
| 英文关键词: sleep deprivation astrocytes A1/A2 reactive astrocytes cognitive dysfunction activation |
| 基金项目:湖北省自然科学基金
项 目（HDAC1STAT3
介导丙泊酚抑制妊娠
期睡眠剥夺致子代神
经炎症的机制研究，
No. 2020CFB335） |
|
| 摘要点击次数: 459 |
| 全文下载次数: 338 |
| 中文摘要: |
| 睡眠剥夺是导致神经炎症、氧化应激及认知功能障碍的重要诱因，其机制与星形胶质细胞的活化密
切相关。星形胶质细胞作为中枢神经系统的关键调控者，通过A1/A2极化表型在睡眠剥夺中发挥双重作
用：A1型通过释放促炎因子和神经毒素加剧神经炎症及突触损伤，而A2型则通过分泌神经营养因子和抗
炎介质促进神经修复。本文系统综述了睡眠剥夺中星形胶质细胞的活化机制及相关信号通路：NF-κB通
路、MAPK通路在、SHH通路和JAK-STAT通路。研究表明，慢性睡眠剥夺通过炎症介质积累及星形胶质
细胞过度激活导致认知障碍，而调控其极化表型（如抑制A1型或增强A2型）可能成为干预睡眠剥夺相关
神经损伤的新策略。未来需进一步解析星形胶质细胞极化的时空特异性及信号网络交互作用，为靶向治
疗提供理论依据。 |
| 英文摘要: |
| Sleep deprivation (SD) is a significant contributor to neuroinflammation, oxidative stress, and
cognitive dysfunction, with its mechanisms closely linked to astrocyte activation. As key regulators of the
central nervous system, astrocytes exhibit dual roles in SD through A1/A2 polarized phenotypes: A1 astrocytes
exacerbate neuroinflammation and synaptic damage by releasing pro-inflammatory factors and neurotoxins,
whereas A2 astrocytes promote neural repair via secretion of neurotrophic factors and anti-inflammatory
mediators. This review systematically summarizes the activation mechanisms of astrocytes in SD and related
signaling pathways, including NF-κB, MAPK, SHH and JAK-STAT. Chronic SD induces cognitive impairment
through the accumulation of inflammatory mediators and hyperactivation of astrocytes, while modulating their
polarization phenotypes (e.g., suppressing A1 or enhancing A2) may serve as novel strategies for intervening in
SD-related neural injuries. Future studies should further elucidate the spatiotemporal specificity of astrocyte
polarization and interactions within signaling networks to provide a theoretical basis for targeted therapies. |
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