| 齐雪
，王伟
，李亚男
，王苏
，高文蔚
，赵博.蛋白质乳酸化修饰及其在神经系统疾病中的研究进展[J].神经损伤功能重建,2024,(知网首发): |
| 蛋白质乳酸化修饰及其在神经系统疾病中的研究进展 |
| Lactylation Modification and Its Research Progress in Neurological Disorders |
| |
| DOI： |
| 中文关键词: 翻译后修饰 乳酸化修饰 神经系统性疾病 |
| 英文关键词: post-translational modifications lactylation neurological diseases |
| 基金项目:国家自然科学基金
项目（cGAS-STING
通路调控 NCOA4
介导的铁自噬在脑
缺血再灌注损伤中
的作用，No. 82102
295） |
|
| 摘要点击次数: 1064 |
| 全文下载次数: 5338 |
| 中文摘要: |
| 乳酸化修饰是新近发现的一种作用于组蛋白和非组蛋白上的翻译后修饰类型。自2019年首次在核心
组蛋白上发现乳酸化修饰位点以来，众多研究者已将目光聚焦于乳酸化修饰与神经系统疾病之间的关系，并
积极探索通过调控乳酸化修饰改善中枢神经系统疾病患者的预后的方法。本文综述了乳酸化修饰与多种神
经系统疾病（如阿尔茨海默病、脑缺血再灌注损伤、新生儿缺血缺氧性脑病）之间的关联及调控机制，拟通过
深入了解乳酸化修饰在不同神经疾病中的作用机制以期为未来研究提供有价值的参考依据。 |
| 英文摘要: |
| Lactylation is a recently discovered post-translational modification that occurs on both histone and
non-histone proteins. Since the identification of lactylation modification sites on core histones by Zhang et al. in
2019, numerous researchers have shifted their focus towards exploring the relationship between lactylation and
neurological disorders, aiming to regulate lactylation to improve the prognosis of central nervous system diseases.
This article provides an overview of the associations and regulatory mechanisms between lactylation and various
neurological disorders, such as Alzheimer’s disease, cerebral ischemia reperfusion injury and hypoxic-ischemic
encephalopathy. By gaining a deeper insight into the mechanistic roles of lactylation in different neurological
diseases, valuable references are provided for future research endeavors. |
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