文章摘要
血管性认知障碍的中医药治疗进展
Progress in the Treatment of Vascular Cognitive Impairment with Traditional Chinese Medicine
投稿时间:2025-08-01  修订日期:2025-08-01
DOI:
中文关键词: 血管性认知障碍  中医药  神经炎症  氧化应激  神经元  线粒体功能
英文关键词: Vascular cognitive impairment  Traditional Chinese Medicine  neuroinflammation  Oxidative stress  Neuron  Mitochondrial function
基金项目:
作者单位邮编
何欣 甘肃中医药大学 730000
袁岳鹏* 甘肃中医药大学附属庆阳市中医医院 
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中文摘要:
      血管性认知障碍(Vascular cognitive impairment,VCI)作为老年及卒中后人群的常见疾病,与高血压、糖尿病等血管危险因素密切相关,随着病情进展最终可发展为血管性痴呆(Vascular Dementia,VD),需要早期干预治疗。目前对于该病的治疗主要依赖于胆碱酯酶抑制剂等,但其疗效有限且副作用多,亟需探索靶向治疗VCI的方法。中医认为本病发病责之于肾精亏虚、痰瘀阻滞,大量临床研究表明中医药能有效改善VCI患者认知功能,疗效确切且安全性良好。本文通过梳理中药单体、中药复方、中成药、针刺及其他外治法防治VCI的临床循证证据及实验研究,发现中医药可以益肾填精、活血化瘀、化痰通络,通过改善线粒体结构与功能、减轻神经炎症、抗氧化应激等作用机制改善患者认知功能,延缓病情进展,以期为VCI的中医药治疗提供实践参考。
英文摘要:
      Vascular cognitive impairment (VCI), as a common disease among the elderly and those after stroke, is closely related to vascular risk factors such as hypertension and diabetes. As the disease progresses, it may eventually develop into vascular dementia (VD). Early intervention and treatment are necessary. Currently, the treatment of this disease mainly relies on cholinesterase inhibitors and other methods, but their efficacy is limited and they have many side effects. Therefore, it is urgent to explore targeted treatment methods for VCI. According to traditional Chinese medicine, the onset of this disease is attributed to the deficiency of kidney essence and the obstruction of phlegm and blood stasis. A large number of clinical studies have shown that traditional Chinese medicine can effectively improve the cognitive function of VCI patients, with definite efficacy and good safety. This article reviews the clinical evidence and experimental studies of traditional Chinese medicine in the prevention and treatment of VCI, including single Chinese herbs, Chinese compound prescriptions, Chinese patent medicines, acupuncture and other external treatments. It is found that traditional Chinese medicine can tonify kidney essence, activate blood circulation, remove phlegm and regulate meridians, and improve the patient's cognitive function through mechanisms such as improving mitochondrial structure and function, reducing neuroinflammation, and antioxidative stress. This aims to provide practical references for the treatment of VCI with traditional Chinese medicine.
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