| Objective: To analyze the related influencing factors of abnormal electromyography in patients with type 2 diabetes mellitus (T2DM) and its optimal cut-off values. Method: A total of 131 patients with T2DM who examined electromyography for the first time in our hospital were selected and divided into the normal electromyography group (N-EMG group，n=64) and the abnormal group (EMG group，n=67) based on the electromyography results. The general data and common clinical indicators of the two groups were compared. Binary logistic regression was used to explore the risk factors of abnormal electromyography in T2DM. The ROC curve was used to analyze the diagnostic efficacy and cut-off values of the risk factors. In addition, the patients were divided into the high urine protein group (H-UPr group) and the low urine protein group (L-UPr group) based on the 24-hour urine protein (24h-UPr) level. Compare the abnormal rates and characteristics of electromyography in the two groups. Result: There were statistically significant differences in age, duration of diabetes, diastolic blood pressure, pulse pressure difference, FBG, HbA1c, FT3, FT4, FT3/FT4, D-dimer, and 24h-UPr between the EMG group and the N-EMG group (P<0.05). Binary logistic regression indicated that age, HbA1c, and 24h-UPr were risk factors for T2DM combined with abnormal electromyography（P<0.05）. The AUC of the combined prediction of electromyogram abnormalities by the three indicators was 0.846, with a sensitivity of 77.42% and a specificity of 77.56%. The cut-off values of ROC were 61.5 years old, 8.20%, and 71.00mg/24h. The abnormal rate of electromyography in the H-UPr group was significantly higher than that in the L-UPr group（P<0.05）, especially the injury of sensory nerves in the tibia and peroneal of the lower extremities（P<0.05）. Conclusion: Older age and higher levels of HbA1c and 24h-UPr are independent risk factors for T2DM combined with abnormal electromyography. The combined detection of the three indicators has greater diagnostic efficacy, especially when the patient's age >61.5 years old, HbA1c >8.20%, 24h-UPr>71.00mg/24h. |