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| 基于肠-肌轴探讨运动介导肠道菌群对骨骼肌萎缩的影响 |
| Investigating How Exercise-induced Changes in the Gut Microbiota Influence Skeletal Muscle Atrophy via the Gut-muscle Axis |
| 投稿时间：2025-07-20 修订日期：2025-07-20 |
| DOI： |
| 中文关键词: 骨骼肌萎缩 肠道菌群 肠-肌轴 运动 炎症 代谢产物 |
| 英文关键词: Skeletal muscle atrophy gut microbiota gut-muscle axis exercise inflammation metabolic products |
| 基金项目: |
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| 中文摘要: |
| 骨骼肌萎缩是多种生理和病理状态下的常见表现，严重影响患者的生活质量和预后。近年来，肠道菌群及其与宿主形成的“肠-肌轴”被认为是影响骨骼肌稳态的关键因素。肠道菌群失调可通过多种途径促进肌肉萎缩，包括破坏肠道屏障、诱发慢性炎症、改变代谢产物谱等。运动是维持骨骼肌质量和功能的有效手段，同时也被证实能够显著调节肠道菌群的组成和功能。越来越多的研究提示，运动可能通过调节肠道菌群，进而通过肠-肌轴对骨骼肌萎缩产生有益影响。本文旨在综述肠-肌轴在骨骼肌萎缩中的作用机制，运动对肠道菌群的影响，并重点探讨运动如何介导肠道菌群变化，从而改善骨骼肌萎缩的潜在机制与临床证据。深入理解这一复杂互作网络，将为开发基于运动和肠道菌群干预的肌肉萎缩防治策略提供新的思路。 |
| 英文摘要: |
| Skeletal muscle atrophy is a common manifestation in various physiological and pathological conditions, profoundly impacting patients’ quality of life and prognosis. In recent years, the gut microbiota and its interaction with the host, conceptualized as the “gut-muscle axis,” have emerged as critical regulators of skeletal muscle homeostasis. Dysbiosis of the gut microbiota can promote muscle atrophy through multiple pathways, including disruption of the intestinal barrier, induction of chronic inflammation, and alteration of metabolic profiles. Exercise is an effective intervention for maintaining muscle mass and function, and it has been shown to significantly modulate the composition and function of the gut microbiota. Increasing evidence suggests that exercise may exert beneficial effects on skeletal muscle atrophy by regulating the gut microbiota and, consequently, the gut-muscle axis. This review aims to summarize the role of the gut-muscle axis in skeletal muscle atrophy, the impact of exercise on gut microbiota, and, in particular, the potential mechanisms and clinical evidence by which exercise-induced modulation of gut microbiota improves muscle atrophy. A deeper understanding of this complex interplay will provide novel insights for developing exercise- and microbiota-based strategies to prevent and treat muscle wasting. |
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