| 肖青辉，李清灿，叶娇，李志方，靳慧娟.急性脑卒中后颅内中性粒细胞的死亡和清除[J].神经损伤功能重建,2025,(7):414-419 |
| 急性脑卒中后颅内中性粒细胞的死亡和清除 |
| Death and Clearance of Intracranial Neutrophils in Acute Ischemic Stroke |
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| DOI： |
| 中文关键词: 急性脑卒中 中性粒细胞 NETosis 凋亡 胞葬 焦亡 反向跨内皮迁移 细胞死亡 |
| 英文关键词: acute ischemic stroke neutrophils NETosis apoptosis efferocytosis pyroptosis reverse
transendothelial migration cell death |
| 基金项目:国家自然科学基金
面上项目（小胶质细
胞通过 CIRBP 诱导
中性粒细胞NETosis
在脑缺血再灌注后
脑水肿中的作用和
机制，No. 82171306） |
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| 摘要点击次数: 39 |
| 全文下载次数: 47 |
| 中文摘要: |
| 脑卒中具高发病率、强致残性、高致死性、高复发率等特点，会显著加大个人与社会的负担。临床上，
急性缺血性脑卒中（acute ischemic stroke，AIS）更为多见，对于其病理过程，炎症反应的作用很显著，AIS
后，外周免疫细胞——中性粒细胞首先被激活并迁移到缺血的脑实质，这些被激活的中性粒细胞寿命延
长，导致持续的炎症反应，造成血脑屏障破坏、脑水肿和神经功能缺损。最近研究发现，颅内中性粒细胞可
以发生NETosis、凋亡和焦亡等死亡方式，被巨噬/小胶质细胞吞噬清除，也可以通过反向跨内皮迁移离开局
部炎症组织。因此，探索颅内中性粒细胞的死亡和清除机制及其对AIS后炎症反应的影响，对改善卒中预
后有重要意义。 |
| 英文摘要: |
| Stroke is characterized by high incidence, disability, mortality, recurrence, which poses a heavy
burden on individuals and society. Acute ischemic stroke (AIS) is particularly common in clinical practice, and
inflammatory response plays a crucial role in its pathological process. After the onset of AIS, neutrophils are the
first activated peripheral immune cells to migrate to the ischemic parenchyma. These activated neutrophils
exhibit a longer lifespan and trigger persistent inflammation that can lead to blood-brain barrier disruption,
cerebral edema, and neurological deficits. Recent studies have found that intracranial neutrophils can undergo
several manner of death: NETosis, apoptosis and pyroptosis. Neutrophils can be phagocytosed and cleared by
macrophages/microglia. Moreover, they can also leave the local inflammatory tissue through reverse
transendothelial migration. Thus, it is of great significance to elucidate the death and clearance mechanism of
intracranial neutrophils for improving the prognosis of AIS. |
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