文章摘要
陈笑一，龙佳欣，田梦芝，彭南波，杜可.细胞自噬在缺血性脑卒中作用的可视化分析[J].神经损伤功能重建,2025,(7):395-401
细胞自噬在缺血性脑卒中作用的可视化分析
Visualization of the Role of Cellular Autophagy in Ischaemic Stroke
  
DOI：
中文关键词: 细胞自噬  缺血性脑卒中  文献计量学  Cite Space  VOS viewe
英文关键词: cellular autophagy  ischemic stroke  bibliometrics  Cite Space  VOS viewer
基金项目:湖南省自然科学基 金项目（黄芪介导 DJ-1/PTEN/mTOR 通路双向调节神经 元自噬抗脑缺血损 伤 机 制 研 究 ，No. 2020JJ9050）；国家 重点实验室开放基 金（NMN介于DJ1调 控 PI3K/Akt/mTOR 通路诱导线粒体自 噬抗脑缺血损伤作 用及机制研究，No. GTZK201711）；研 究生创新创业训练 计划项目（血筒素 介导 PTEN/mTOR/ HIF-1α通路调控自 噬抗缺血性卒中的 机制研究，No. CX2 0230828）；2022 年 度湖南省普通高等 学校教学改革研究 项目（《药理学》课 程思政构建，培养 同频共振专业人才 及队伍，No. HNJG- 2022-0134 重点项）
作者单位
陈笑一，龙佳欣，田梦芝，彭南波，杜可 湖南中医药大学药 学院药理实验室 
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中文摘要:
      目的：基于文献计量学对细胞自噬在缺血性脑卒中作用的研究现状与前沿热点进行分析和总结。方 法：以中国知网、万方数据和Web of science数据库核心合集检索文献，采用软件Cite Space、VOS viewer以 及R语言文献计量学包Bibliometrix对2013～2023年已经发表的文献进行发文量、国家、作者合作、机构合 作、关键词、共现网络的可视化分析。结果：纳入的中、英文文献发文量趋于稳定，最近几年呈上升趋势，研 究热度不减；中国为发文量第一的国家；田福玲和陈忠分别是中、英文文献发文量最多的作者；安徽中医药 大学和浙江大学分别是中、英文文献发文量最多的机构；中医药联用、外泌体、串扰效应、机制研究可能是 未来几年的研究热点。结论：未来广大科研人员在细胞自噬的具体作用机制、效应、中药来源创新药物研 发等方面的研究有待深入，可以通过基因敲除、网络药理学等方法来探究具体作用机制，可尝试中药“以药 寻靶”为策略，解析中药药效物质、揭示中药新靶标以及开发中药创新药物。
英文摘要:
      To analyze and summarize the current research status and frontiers of the role of autophagy in ischemic stroke based on bibliometrics. Methods: Literature was retrieved from the core collections of the China National Knowledge Infrastructure (CNKI), Wanfang Data, and Web of Science databases. Software tools such as Cite Space, VOS viewer, and the bibliometric package Bibliometrix in R language were employed to conduct visual analyses on the number of publications, contributing countries, author collaborations, institutional collaborations, keywords, and co-occurrence networks of the published literature from 2013 to 2023. Results: The number of included Chinese and English publications has shown a stable trend in recent years, with an upward trajectory observed, indicating sustained research interest. China ranks first in terms of the number of publications. TIAN Fuling and CHEN Zhong are the most prolific authors in Chinese and English literature, respectively. Anhui University of Chinese Medicine and Zhejiang University are the institutions with the highest number of publications in Chinese and English literature, respectively. Research hotspots in the coming years may include the combination of traditional Chinese medicine (TCM), exosomes, crosstalk effects, and mechanistic studies. Conclusion: Future research by scientists should delve deeper into the specific mechanisms and effects of autophagy, as well as the development of innovative drugs derived from TCM. Methods such as gene knockout and network pharmacology can be utilized to explore the specific mechanisms of action. The strategy of "target identification through drugs" in TCM can be attempted to elucidate the pharmacodynamic substances of TCM, reveal new TCM targets, and develop innovative TCM drugs.
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