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| 单核苷酸多态性与强迫症的关联 |
| The Association between Single Nucleotide Polymorphism and Obsessive-compulsive Disorder |
| 投稿时间：2025-06-24 修订日期：2025-06-24 |
| DOI： |
| 中文关键词: 强迫症 遗传学 基因多态性 单核苷酸多态性 |
| 英文关键词: Obsessive-compulsive disorder genetics genetic polymorphism single nucleotide polymorphism |
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| 中文摘要: |
| 强迫症是一种以不必要的强迫思维和强迫行为为主要特征的高致残性精神疾病。在遗传学方面，中枢神经系统中的5-羟色胺、谷氨酸、多巴胺能系统功能的异常，炎症反应、细胞内信号传导等生物学过程的异常等方面均可能与强迫症的发生和发展有关，而单核苷酸多态性可能是在分子生物学层面导致这些异常的重要原因。因此研究不同发病机制中的热门候选基因多态性对于分析强迫症发病机制至关重要，并且在预测强迫症的危险因素以及准确治疗方面存在潜力。 |
| 英文摘要: |
| Obsessive-compulsive disorder(OCD) is a highly disabling mental illness characterized primarily by unnecessary compulsive thinking and behavior. In terms of genetics, abnormalities in the functions of the serotonin, glutamate, and dopaminergic systems in the central nervous system, as well as abnormalities in biological processes such as inflammation and intracellular signal transduction, may be related to the occurrence and development of obsessive-compulsive disorder. Single nucleotide polymorphism may be an important reason for these abnormalities at the molecular biology level. Therefore, studying the polymorphisms of popular candidate genes in different pathogenesis mechanisms is crucial for analyzing the pathogenesis of obsessive-compulsive disorder, and there is potential in predicting risk factors and accurate treatment of obsessive-compulsive disorder. |
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