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| 缺血性卒中患者的神经网络去抑制与代偿：来自静息态与任务态 fNIRS 的证据 |
| Neural Network Disinhibition and Compensation in Ischemic Stroke Patients: Evidence from Resting-State and Task-State fNIRS |
| 投稿时间：2025-06-18 修订日期：2025-06-18 |
| DOI： |
| 中文关键词: 卒中 功能性近红外光谱 去抑制 代偿 神经网络 静息态 VFT任务态 |
| 英文关键词: Stroke Functional Near-Infrared Spectroscopy (fNIRS) Disinhibition Compensation Neural Network Resting-State VFT Task-State |
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| 中文摘要: |
| 目的：本研究旨在探讨卒中后大脑的去抑制与代偿机制,使用功能性近红外光谱(fNIRS)技术分析卒中患者与健康对照组在静息态和任务态下的大脑皮层氧合变化,进一步理解神经网络的重组及其在认知功能恢复中的作用。方法：研究对象为27例脑卒中患者和15例健康对照组。通过fNIRS设备采集静息态(5分钟)和言语流畅性任务(VFT)期间的脑部血氧变化数据。结果：静息态分析显示,卒中组在涉及多个脑区的26组通道(如背外侧前额叶皮层、躯体感觉皮层等)的功能连接强度较健康对照组显著较高,提示卒中组可能存在过度激活和代偿机制。在VFT任务态下,卒中组在右侧DLPFC、右侧Broca区和左侧SSC的激活显著高于健康对照组(P<0.05)。进一步分析显示右侧DLPFC、右侧Broca区血氧浓度存在显著差异(P<0.05),而左侧SSC未见明显差异。结论：静息态和任务态下的大脑功能变化反映了卒中后大脑的去抑制与代偿机制,表明卒中组的大脑网络功能可能存在不同的神经适应和重组现象。 |
| 英文摘要: |
| Objective: This study aims to investigate the mechanisms of disinhibition and compensation in the post-stroke brain by using functional near-infrared spectroscopy (fNIRS) to analyze cortical oxygenation changes in stroke patients and healthy controls during both resting-state and task-state conditions. The study seeks to further understand neural network reorganization and its role in cognitive recovery.Methods: A total of 27 stroke patients and 15 healthy controls were recruited. Brain oxygenation changes were recorded using fNIRS during a 5-minute resting-state session and a verbal fluency task (VFT).Results: Resting-state analysis revealed significantly higher functional connectivity in 26 channel pairs involving multiple brain regions, such as the dorsolateral prefrontal cortex (DLPFC) and somatosensory cortex (SSC), in the stroke group compared to the healthy controls. This suggests the presence of excessive activation and compensatory mechanisms in stroke patients. During the VFT, the stroke group exhibited significantly higher activation in the right DLPFC, right Broca’s area, and left SSC compared to the healthy controls (P < 0.05). Further analysis showed significant differences in oxygenation levels in the right DLPFC and right Broca’s area (P < 0.05), whereas no significant differences were observed in the left SSC.Conclusion: Changes in brain function during resting-state and task-state conditions reflect mechanisms of disinhibition and compensation in post-stroke patients. These findings suggest that neural network function in stroke patients undergoes distinct neuroadaptive and reorganization processes. |
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