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| 血脑屏障外周血生物标志物与帕金森病及帕金森病认知障碍相关性研究 |
| Study on the correlation between peripheral blood biomarkers of blood-brain barrier and Parkinson 's disease and cognitive impairment of Parkinson 's |
| 投稿时间：2025-06-12 修订日期：2025-06-12 |
| DOI： |
| 中文关键词: 帕金森病 认知障碍 血脑屏障 外周血 生物标志物 |
| 英文关键词: Parkinson's disease cognitive impairment Blood brain barrier Peripheral blood Biomarker |
| 基金项目:自治区重点研发专项（探讨针刺治疗对PD免疫失调机制影响的相关性研究，建立中西医临床共识的诊疗规范） |
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| 中文摘要: |
| 帕金森病是一种中枢神经系统退行性疾病，常合并多种非运动症状，认知功能障碍是其重要的非运动症状，严重影响患者生活质量，但帕金森病伴认知障碍的发病机制尚不明确。血脑屏障的破坏被认为介导和参与帕金森病及帕金森病伴认知障碍，并且影响病程进展。S100钙结合蛋白B 、闭合蛋白、封闭蛋白-5、水通道蛋白-4、胶质纤维酸性蛋白、基质金属蛋白酶-9均为反映血脑屏障破坏的标志物，同时在帕金森病及帕金森病伴认知障碍的病理生理过程中也扮演重要角色。因此本文将阐述这些特异性蛋白作为血脑屏障破坏的外周生物标志物以及与帕金森病、帕金森病伴认知障碍发展之间的相关性研究进展。 |
| 英文摘要: |
| Parkinson 's disease is a degenerative disease of the central nervous system, which is often accompanied by a variety of non-motor symptoms. Cognitive dysfunction is an important non-motor symptom, which seriously affects the quality of life of patients. However, the pathogenesis of Parkinson 's disease with cognitive impairment is not clear. The destruction of the blood-brain barrier is believed to mediate and participate in Parkinson 's disease and Parkinson 's disease with cognitive impairment, and affect the progression of the disease. S100 calcium binding protein B, occludin, occludin-5, aquaporin-4, glial fibrillary acidic protein and matrix metalloproteinase-9 are all markers reflecting the destruction of blood-brain barrier, and also play an important role in the pathophysiological process of Parkinson 's disease and Parkinson 's disease with cognitive impairment. Therefore, this article will elaborate on the research progress of these specific proteins as peripheral biomarkers of blood-brain barrier damage and their correlation with the development of Parkinson 's disease and Parkinson 's disease with cognitive impairment. |
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