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| 光污染与癫痫及生物节律的交叉影响机制研究 |
| Research on the Cross-Impact Mechanisms of Light Pollution, Epilepsy, and Biological Rhythms |
| 投稿时间：2025-05-26 修订日期：2025-05-26 |
| DOI： |
| 中文关键词: 光污染、光敏性癫痫、生物节律、褪黑素、神经兴奋性 |
| 英文关键词: Light pollution Photosensitive epilepsy Circadian rhythm Melatonin Neuronal hyperexcitability |
| 基金项目: |
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| 中文摘要: |
| 光污染作为现代神经科学新兴研究领域，其对神经系统疾病的潜在影响日益引起关注。本综述系统性探讨了光污染与光敏性癫痫（PSE）的复杂关联机制。研究发现，光污染尤其是蓝光（480 nm）通过视网膜非成像细胞（ipRGCs）直接抑制褪黑素分泌，并间接破坏生物节律，显著增加癫痫发作风险。关键机制包括：神经元兴奋性异常升高、生物钟基因表达紊乱，以及通过氧化应激和神经炎症加剧癫痫病理进程。干预策略涵盖时间疗法、褪黑素补充和公共卫生措施。未来研究应聚焦多学科交叉、新技术应用，开发基于个体化的精准预防与治疗策略，为缓解光污染对神经系统的潜在危害提供科学依据。 |
| 英文摘要: |
| Abstract: As an emerging research domain in modern neuroscience, the potential impacts of light pollution on neurological disorders have garnered increasing scientific attention. This review systematically investigates the complex interaction mechanisms between light pollution and photosensitive epilepsy (PSE). Evidence indicates that light pollution, particularly blue light exposure at 480 nm, significantly elevates seizure susceptibility through two principal pathways: primarily through direct suppression of melatonin secretion via intrinsically photosensitive retinal ganglion cells (ipRGCs) and secondary disruption of circadian rhythms. Core mechanisms involve three pathological dimensions: abnormal elevation of neuronal excitability, dysregulation of circadian clock gene expression patterns, and exacerbation of epileptogenic processes through oxidative stress and neuroinflammatory pathways. Current intervention strategies encompass chronotherapeutic approaches, melatonin supplementation protocols, and public health policy initiatives. Future research directions should emphasize interdisciplinary integration, innovative technology implementation, and development of personalized precision prevention frameworks. These advancements aim to establish an evidence-based scientific foundation for mitigating the latent neurological risks associated with light pollution. |
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