|
| 表观遗传修饰与抑郁症相关突触可塑性的研究进展 |
| Research progress on epigenetic modifications and synaptic plasticity associated with depression |
| 投稿时间：2025-05-15 修订日期：2025-05-15 |
| DOI： |
| 中文关键词: 抑郁症 突触可塑性 非编码RNA DNA甲基化 组蛋白修饰 RNA m6A修饰 |
| 英文关键词: Depression Synaptic plasticity Non coding RNA DNA methylation Histone modification RNA m6A modification |
| 基金项目:基金项目：黑龙江省自然科学基金项目（编号：LH2023H021）；黑龙江省卫生健康委科研项目（编号：20220303090993）；大庆市指导性科技计划项目（编号：zdy-2023-28）； |
|
| 摘要点击次数: 5 |
| 全文下载次数: 0 |
| 中文摘要: |
| 抑郁症是一种病因学复杂的精神类疾病，受遗传因素和环境因素影响。突触可塑性降低是抑郁症的病因之一。表观遗传学是一个快速发展的生物学领域，主要研究基因表达的变化，这些变化不是由于DNA序列的变动，而是通过DNA甲基化、RNA m6A修饰、组蛋白修饰、非编码RNA等方式进行基因调控，表观遗传学修饰参与了突触可塑性调节，并在抑郁症的发病机制中发挥重要的作用。本文章主要总结了表观遗传学对突触可塑性的影响在抑郁症发病机制及治疗中的作用机制，为抑郁症的病因学研究及治疗靶点提供新的思路。 |
| 英文摘要: |
| Depression is a mental disease with complex etiology, which is affected by genetic factors and environmental factors. The decrease of synaptic plasticity is one of the causes of depression. Epigenetics is a rapidly developing field of biology, which mainly studies the changes of gene expression. These changes are not due to the changes of DNA sequence, but through DNA methylation, RNA m6A modification, histone modification, non coding RNA and other ways of gene regulation. Epigenetic modification is involved in the regulation of synaptic plasticity and plays an important role in the pathogenesis of depression. This article mainly summarizes the mechanism of the effect of epigenetics on synaptic plasticity in the pathogenesis and treatment of depression, and provides new ideas for the etiological research and treatment targets of depression. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |