| 陈曾青，吴艳萍，罗涛，操基清，陈真真，曾铮，李昌俊，经屏.缺血性脑卒中急性期抑郁状态与1年后认知
及生活功能的相关性研究[J].神经损伤功能重建,2025,(5):256-259 |
| 缺血性脑卒中急性期抑郁状态与1年后认知
及生活功能的相关性研究 |
| Correlation between Depressive Symptoms in Acute Phase of Ischemic Stroke and Cognitiveand Life Function One Year later |
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| DOI： |
| 中文关键词: 急性缺血性脑卒中 抑郁状态 认知障碍 生活功能 |
| 英文关键词: acute ischemic stroke depressive symptoms cognitive impairment life function |
| 基金项目:国家重点研发计划
（卒中后抑郁的多
维度筛查防治技术
开发与应用-卒中
后抑郁危险因素预
测评估，No. 2017Y
FC1310000） |
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| 中文摘要: |
| 目的：探讨缺血性脑卒中急性期抑郁状态与1年后认知及生活功能的相关性。方法：收集2018年6月
至2019年6月在武汉市中心医院及同济医院住院的急性缺血性脑卒中（acute ischemic stroke，AIS）患者的
临床资料。出院时，采用流调中心抑郁自评量表（Center for Epidemiological Studies Depression Scale，
CES-D）评估卒中后抑郁状态（post stroke depression symptoms，PSDS）的程度。随访1年，采用简易精神状
态量表（Mini-Mental State Examination，MMSE）评估认知功能，采用改良的 Rankin 量表（modified Rankin
Scale，mRS）评估生活功能。运用多因素Logistic回归分析PSDS与卒中1年后功能预后的相关性。结果：
共纳入 219 例 AIS 患者，根据卒中急性期是否有抑郁状态分为 PSDS 组和非 PSDS 组。基线数据分析显
示，PSDS组的BMI及卒中类型与非PSDS组相比差异有统计学意义（P＜0.05）。多因素Logistic回归分析
结果显示，与非PSDS组相比，PSDS组在卒中1年后认知障碍患者的比例更低（P＜0.001），在mRS良好预后
的比例上，2组之间差异无统计学意义。结论：缺血性脑卒中急性期抑郁状态与卒中1年后发生认知障碍的
风险升高显著相关，与良好生活功能预后无相关性。 |
| 英文摘要: |
| To investigate the correlation between depressive state during the acute phase of
ischemic stroke and cognitive/functional outcomes one year later. Methods: Clinical data were collected from
patients with acute ischemic stroke (AIS) admitted to Wuhan Central Hospital and Tongji Hospital from June
2018 to June 2019. At discharge, the severity of post-stroke depressive state was assessed using the Center for
Epidemiological Studies Depression Scale (CES-D). During a one-year follow-up, cognitive function was
evaluated using the Mini-Mental State Examination (MMSE), and functional outcome was assessed using the
modified Rankin Scale (mRS). Multivariate logistic regression analysis was performed to examine the
correlation between post-stroke depressive state (PSDS) and functional prognosis one year after stroke. Results:
A total of 219 AIS patients were included and divided into PSDS and non-PSDS groups based on the presence of
depressive state during the acute stroke phase. Baseline data analysis revealed significant differences in BMI and
stroke type between the PSDS and non-PSDS groups (P<0.05). Multivariate logistic regression analysis
indicated that compared to the non-PSDS group, the PSDS group had a significantly lower proportion of patients
with cognitive impairment one year after stroke (P<0.001), while no statistically significant difference was
observed between the two groups in the proportion of patients with good mRS prognosis. Conclusion:
Depressive state during the acute phase of ischemic stroke is significantly associated with an increased risk of
cognitive impairment one year after stroke but is not correlated with favorable functional outcome. |
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