| 耿敏霞,
，郭卫娜
，陈景红
，李爽,
，邢佳豪,
，王天俊.定量磁敏感成像在帕金森病脑铁沉积研究中的应用[J].神经损伤功能重建,2025,(4):211-214 |
| 定量磁敏感成像在帕金森病脑铁沉积研究中的应用 |
| Application of Quantitative Susceptibility Mapping in the Study of Brain Iron Deposition inParkinson's Disease |
| |
| DOI： |
| 中文关键词: 帕金森病 定量磁敏感成像 铁沉积 诊断 |
| 英文关键词: Parkinson's disease quantitative susceptibility mapping Iron deposition Diagnosis |
| 基金项目:河北省医学科学研
究课题计划（重复经
颅磁刺激对帕金森
病不同临床亚型患
者的疗效观察，No.
20230013） |
|
| 摘要点击次数: 104 |
| 全文下载次数: 114 |
| 中文摘要: |
| 帕金森病（Parkinson’s disease，PD）是最常见的神经退行性疾病之一。定量磁敏感成像（quantitative
susceptibility mapping，QSM）通过磁共振采集数据的无创方式使脑铁含量量化成为可能，这有助于了解铁
沉积在PD发病机制中的作用，有望成为一种新型的PD生物标志物。本文通过简述基于脑内铁沉积原理的
QSM在PD运动症状、非运动症状、治疗及鉴别中的研究进展，为QSM在PD及疾病早期诊断中提供了可靠
的影像学依据，对PD患者病情评估及寻找新的治疗方法具有重要意义，从而为理解疾病条件下的脑铁生理
学提出了一条新途径。 |
| 英文摘要: |
| Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Quantitative Susceptibility Mapping (QSM), a non-invasive method that utilizes magnetic resonance data acquisition, makes it
possible to quantify brain iron content. This helps to understand the role of iron deposition in the pathogenesis of
PD and is expected to become a new type of biomarker for PD. This paper briefly describes the research progress
of QSM based on the principle of intracranial iron deposition in the motor symptoms, non-motor symptoms,
treatment, and differential diagnosis of PD, providing a reliable imaging basis for QSM in the early diagnosis of
PD and diseases. It is of great significance for the assessment of the condition of PD patients and the search for
new treatment methods, thus proposing a new approach to understanding the brain iron physiology under disease
conditions. |
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