| 王华捷
，袁江
，朱敬
，王自涵
，任凤
，王丽
，王云甫.非运动症状量表鉴别药物诱发的帕金森综合症的可行性研究[J].神经损伤功能重建,2025,(4):203-206 |
| 非运动症状量表鉴别药物诱发的帕金森综合症的可行性研究 |
| A Feasibility Study on the Use of the Non-motor Symptoms Scale to DifferentiateDrug-induced Parkinsonism |
| |
| DOI： |
| 中文关键词: 帕金森病 药物诱发的帕金森综合症 非运动症状 |
| 英文关键词: Parkinson's disease drug-induced parkinsonism Non-motor symptoms |
| 基金项目:湖北省自然科学基
金项目（Notch1 介
导线粒体自噬影响
Treg细胞功能参与
重症肌无力发病的
机制研究，No. 202
4AFB818）；湖北医
药学院研究生科技
创新项目[T 细胞
免 疫 球 蛋 白 黏 蛋
白-4（TIM-4）调控
小 胶 质 细 胞 极 化
（M1/M2）对脑出血
的影响，No. YC20
23051] |
|
| 摘要点击次数: 102 |
| 全文下载次数: 114 |
| 中文摘要: |
| 目的：探讨使用非运动症状量表（non-motor symptoms scale，NMSS）协助鉴别药物诱发的帕金森综合
症（drug-induced parkinsonism，DIP）与帕金森病（Parkinson's disease，PD）的可行性。方法：选取2023年5月
～2024年5月就诊于我院神经内科的DIP患者21例（DIP组），未经药物治疗的PD患者25例（PD组）及无帕
金森症状的患者22例（对照组）。收集患者临床资料，使用统一帕金森量表Ⅲ（UPDRS Ⅲ）和Hoehn-Yahr分
级量表（Hoehn and Yahr stage scale，H-Y）对患者进行评估，同时使用NMSS对非运动症状进行评估；比较、分
析3组患者的各量表得分及相关性。结果：DIP组、PD组的NMSS单项得分与对照组相比差异显著，除感知
（被害妄想、复视），注意力、记忆力（近事记忆困难、遗忘做一些事情），胃肠道症状（吞咽困难），其他（出汗增
多）外，其他项目得分差异均有统计学意义（P＜0.05）。DIP组和PD组相比，两者的血管症状，睡眠体力（白
天嗜睡、不安腿），注意力记忆力（注意力不集中），胃肠道症状（流涎），泌尿系症状，性功能，其他（不能解释
的疼痛、味觉嗅觉改变）项目得分差异有统计学意义（P＜0.05）；Spearman相关分析结果显示，DIP组和PD组
的运动症状相关性（UPDRS Ⅲ和H-Y）低到中度相关（rs=－0.254, －0.519）；其他各项中，DIP组只有睡眠体
力（白天嗜睡），注意力记忆力（注意力不集中），泌尿系症状，其他（味觉及嗅觉改变）与PD组呈中等程度相
关（rs=0.370～0.497）；睡眠体力（不宁腿）与PD组为低等程度相关（rs=0.279）；其余项目均未发现显著相关性
（P＞0.05）。结论：NMSS评分有助于提高鉴别早期DIP和PD患者的准确性。 |
| 英文摘要: |
| To explore the feasibility of using the Non-motor Symptoms Scale (NMSS) to assist in
differentiating drug-induced parkinsonism (DIP) from Parkinson's disease (PD). Methods: A total of 21 patients
with DIP (DIP group), 25 patients with PD who had not received medication treatment (PD group), and 22
patients without Parkinson's symptoms (control group) were selected from May 2023 to May 2024 in the
Department of Neurology of our hospital. Clinical data of the patients were collected, and they were assessed
using the Unified Parkinson's Disease Rating Scale Part III (UPDRS III) and the Hoehn and Yahr Staging Scale
(H-Y). At the same time, the NMSS was used to evaluate the non-motor symptoms. The scale scores and their
correlations among the three groups were compared and analyzed. Results: The scores of the NMSS in the DIP
group and PD group showed significant differences compared with the control group. Except for perception
(delusions of persecution, diplopia), attention and memory (difficulty remembering recent events, forgetting to do
some things), gastrointestinal symptoms (dysphagia), and others (increased sweating), the differences in other
items were statistically significant (P<0.05). Compared with the PD group, the scores of vascular symptoms,
sleep and physical strength (daytime sleepiness, restless legs syndrome), attention and memory (inattentiveness),
gastrointestinal symptoms (ptyalism), urinary symptoms, sexual function, and others (unexplained pain, alteration
of taste and smell sense) in the DIP group were statistically significant (P<0.05). Spearman correlation analysis
showed that the motor symptoms correlation (UPDRS III and H-Y) in the DIP group and PD group was low to
moderately correlated (rs=－0.254, －0.519). Among other items, only sleep and physical strength (daytime sleepiness), attention and memory (inattentiveness), urinary symptoms, and others (alteration of taste and smell senses)
in the DIP group were moderately correlated with those in the PD group (rs=0.370～0.497); sleep and physical
strength (restless legs syndrome) was lowly correlated with the PD group (rs=0.279). No significant correlation
was found in the remaining items (P>0.05). Conclusion: The NMSS score is helpful to improve the accuracy of
differentiating early DIP from PD patients. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|