| 【Abstract】Objective: To explore the effects of different frequencies of peripheral nerve magnetic stimulation on cortical nerve function, and provide favorable reference for clinical peripheral magnetic stimulation treatment parameters. Method: This study included 20 healthy adults who underwent peripheral magnetic stimulation at 10Hz, 20Hz, and 30Hz on different dates to stimulate the extensor carpi dorsi muscle group. We observed whether different frequencies of stimulation caused different changes in cerebral hemodynamics. To exclude the influence of other factors, we set fixed stimulation time, interval time, and total pulse number to avoid changes caused by differences in total and interval time. The study adopted the recommended guidelines for peripheral magnetic stimulation, with a duration of 2 seconds of stimulation and 8 seconds of rest, totaling 2400 pulses. Before and after magnetic stimulation treatment, near-infrared functional brain imaging (fNIRs) technology was used to collect the concentration of oxygenated hemoglobin in the cerebral cortex of subjects. Result: In healthy adults, all three paradigms of peripheral magnetic stimulation in this experiment caused changes in cerebral cortical hemodynamics (P<0.05). By analyzing the resting state data of the right wrist extensor muscle group before and after stimulation, it was found that channels 10, 11, 12, 15, 18, 28, 42, and 47 all showed significant changes in oxygenated hemoglobin concentration after intervention. Among them, magnetic stimulation at a frequency of 20Hz caused the most changes in the cerebral cortex, with the main areas being the dorsolateral side of the right frontal lobe, left and right somatosensory cortex, left and right auxiliary motor cortex, and left and right Broca area. Among all channels with differences, we found that there were differences between the 10Hz group and the 20Hz group, as well as between the 10Hz and 30Hz groups, while there were no differences between the 20Hz and 30Hz groups. Conclusion: fNIRs can reflect real-time changes in cortical hemodynamic response caused by peripheral nerve magnetic stimulation; Peripheral magnetic stimulation of different paradigms can cause changes in the hemodynamics of the cerebral cortex, with 20Hz frequency magnetic stimulation activating the most significant regions. |