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| 生物钟节律紊乱介导抑郁-失眠共病的研究进展 |
| Advances in the study of biological clock rhythm disorders mediating depression-insomnia co-morbidity |
| 投稿时间：2025-03-26 修订日期：2025-03-26 |
| DOI： |
| 中文关键词: 抑郁 失眠 生物钟基因 昼夜节律 睡眠-觉醒 |
| 英文关键词: depression Insomnia clock gene circadian rhythms sleep-wake |
| 基金项目:国家中医药管理局高水平中医药重点学科建设项目（14061230010）； |
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| 中文摘要: |
| 随着社会节奏加快及作息模式改变，抑郁与失眠共病患病率呈显著上升趋势。临床数据显示，共病患者存在药物不良反应显著、缓解率低及复发率高等局限性。近年研究揭示，昼夜节律系统可能通过“生物钟基因-神经环路-行为表型”多级调控网络同时影响睡眠结构与情绪调节。本文从昼夜节律介导下的睡眠结构出发，探讨抑郁失眠共病机制，通过对生物钟基因层面、神经通路机制、抑郁失眠临床表型等多层面的深入探究，揭示其与睡眠-觉醒、情绪调节之间的双向关联，为理解抑郁失眠共病的内在机制提供关键线索，也为开发新型双靶点药物及个体化疗法提供理论框架，为突破当前临床治疗瓶颈探寻新方向。 |
| 英文摘要: |
| The prevalence of depression and insomnia co-morbidity is increasing significantly with the accelerated pace of society and changes in work and rest patterns. Clinical data show that patients with co-occurring disorders have significant adverse drug effects, low remission rates and high relapse rates. Recent studies have revealed that the circadian system may affect both sleep structure and mood regulation through a multilevel network of biological clock genes, neural circuits and behavioural phenotypes. In this paper, we explored the co-morbid mechanism of depression and insomnia from the perspective of circadian rhythm-mediated sleep structure, and revealed its close association with sleep-wakefulness and emotion regulation through the in-depth investigation of biological clock genes, neurological pathway mechanisms, and clinical phenotypes of depression and insomnia, so as to provide the key clues for the understanding of the intrinsic mechanism of the co-morbid disease of depression and insomnia and the theoretical framework for the development of novel dual-targeted drugs and individualised therapies, and to break through the current clinical treatment bottleneck. It also provides a theoretical framework for the development of novel dual-target drugs and individualised therapies, and a new direction for breaking through the current bottleneck in clinical treatment. |
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