| 刘益萌
，赵丽
，王玥.小胶质细胞TREM2在阿尔茨海默病发病机制中作用的研究进展[J].神经损伤功能重建,2025,(3):166-169 |
| 小胶质细胞TREM2在阿尔茨海默病发病机制中作用的研究进展 |
| Advances in the Roles of TREM2 in Microglia in Pathogenesis of Alzheimer's Disease |
| |
| DOI： |
| 中文关键词: 阿尔茨海默病 小胶质细胞 髓系细胞触发受体2 |
| 英文关键词: Alzheimer's disease microglia triggering receptor expressed on myeloid cells 2 |
| 基金项目:北京市自然科学基
金（TREM2 介导小
胶质细胞自噬减轻
1 型糖尿病认知功
能障碍的作用及机
制，No. 7232003）；
国家自然科学基金
（TREM2 调 控
DAM在1型糖尿病
认知功能障碍中作
用 及 其 机 制 ，No.
82071539） |
|
| 摘要点击次数: 80 |
| 全文下载次数: 78 |
| 中文摘要: |
| 阿尔茨海默病（Alzheimer's disease，AD）常见于老年人，临床表现为记忆力减退、精神行为异常等。
AD的发病机制目前尚不清楚，目前存在的多种假说并不能完全解释AD的全部发病特征。小胶质细胞是脑
组织中特殊的巨噬细胞，可监测周围神经元和胶质细胞的健康情况，同时具有神经保护和神经毒性作用。
近年来通过对AD的不断深入研究发现，小胶质细胞通过髓系细胞触发受体2（triggering receptor expressed
on myeloid cells 2，TREM2）参与AD发病机制，TREM2功能丧失会加剧AD的发展进程。本文就TREM2及
其突变体介导小胶质细胞功能改变在AD发生发展中的作用进行综述。 |
| 英文摘要: |
| Alzheimer's disease (AD), commonly observed in the elderly, manifests clinically with symptoms
such as memory decline and neuropsychiatric abnormalities. The pathogenesis of AD remains unclear to date, as
the various existing hypotheses fail to fully account for all the disease characteristics of AD. Microglia,
specialized macrophages in brain tissue, monitor the health of surrounding neurons and glial cells, exhibiting
both neuroprotective and neurotoxic effects. Recent in-depth research on AD has revealed that microglia
participate in the pathogenesis of AD through the triggering receptor expressed on myeloid cells 2 (TREM2).
Loss of TREM2 function exacerbates the progression of AD. This article reviews the role of TREM2 and its
mutants in mediating microglial functional alterations during the occurrence and development of AD. |
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