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| 星形胶质细胞在睡眠剥夺中的作用及其机制 |
| Research on the Role and Mechanisms of Astrocyte Activation in Sleep Deprivation |
| 投稿时间：2025-03-03 修订日期：2025-03-03 |
| DOI： |
| 中文关键词: 睡眠剥夺 星形胶质细胞 A1/A2反应性星形胶质细胞 认知功能障碍 活化 |
| 英文关键词: leep Deprivation Astrocytes A1/A2 Reactive Astrocytes Cognitive Dysfunction Activation |
| 基金项目:(2020CFB335)通讯作者 罗向红95luoxianghong@163.com项目题目 HDAC1STAT3介导丙泊酚抑制妊娠期睡眠剥夺致子代神经炎症的机制研究 研究发现反应性星形胶质细胞分为两种类型：神经毒性(A1)和神经保护性(A2),这为该疾病的发病机制提供了新的视角。本文概述星形胶质细胞在睡眠剥夺中的作用,重点介绍了有关星形胶质细胞表型及其控制机制。 |
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| 中文摘要: |
| 睡眠在维持人类生理与心理健康过程起着关键作用。越来越多的证据表明,睡眠剥夺(Sleep Deprivation)对神经系统的结构与功能产生了显著影响,包括死亡、认知功能障碍等。虽然目前不了解病理机制,且临床也未得到好的解决睡眠剥夺方法。最近研究表明,星形胶质细胞在中枢神经系统疾病时发挥重要的作用。星形胶质细胞可以支持神经元的存活,促进突触形成以及重塑,也可以分泌促炎因子加重神经系统疾病。在中枢神经系统疾病中,星形胶质细胞会活化并改变其功能特性,被称为反应性星形胶质细胞。研究发现反应性星形胶质细胞分为两种类型：神经毒性(A1)和神经保护性(A2),这为该疾病的发病机制提供了新的视角。本文概述星形胶质细胞在睡眠剥夺中的作用,重点介绍了有关星形胶质细胞表型及其控制机制。 |
| 英文摘要: |
| Sleep plays a crucial role in maintaining human physiological and psychological health. Increasing evidence indicates that sleep deprivation significantly impacts the structure and function of the nervous system, leading to outcomes such as mortality and cognitive dysfunction. Despite this, the pathological mechanisms remain unclear, and effective clinical solutions for sleep deprivation are still lacking. Recent research highlights that astrocytes play an essential role in central nervous system (CNS) disorders. Astrocytes support neuronal survival, promote synapse formation and remodeling, and can also release pro-inflammatory factors that exacerbate neurological disorders. In CNS diseases, astrocytes become activated and undergo functional changes, known as reactive astrocytes. Studies have identified two types of reactive astrocytes: neurotoxic (A1) and neuroprotective (A2), offering a new perspective on the pathogenesis of these diseases. This paper summarizes the role of astrocytes in sleep deprivation, with a focus on astrocyte phenotypes and their regulatory mechanisms. |
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