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基于线粒体稳态的慢性疲劳综合征发病机制研究进展 |
Research Progress on the Pathogenesis of Chronic Fatigue Syndrome Based on Mitochondrial Homeostasis |
投稿时间:2025-02-19 修订日期:2025-02-19 |
DOI: |
中文关键词: 慢性疲劳综合征 线粒体 稳态 |
英文关键词: Chronic fatigue syndrome mitochondria homeostasis |
基金项目: |
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中文摘要: |
慢性疲劳综合征(chronic fatigue syndrome,CFS)与线粒体稳态失衡密切相关,研究显示CFS患者或模型动物的线粒体在形态结构、代谢及质量控制等方面存在异常,与CFS发生和(或)发展关系密切。本文以线粒体稳态为切入点,系统梳理其在CFS发病中影响与作用,以期为慢性疲劳综合征的潜在机制研究和治疗提供更多的思路和策略。 |
英文摘要: |
Chronic fatigue syndrome (CFS) is closely related to the imbalance of mitochondrial homeostasis, and studies have shown that mitochondria in CFS patients or model animals have abnormalities in morphology and structure, metabolism and quality control, which are closely related to the occurrence and/or development of CFS. In this paper, we take mitochondrial homeostasis as an entry point to systematically sort out its influence and role in the pathogenesis of CFS, with a view to providing more ideas and strategies for the study of potential mechanisms and treatment of chronic fatigue syndrome. |
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