| 陈娟
，庄奥林
，柳州
，满劲进
，陈丹阳
，李盛杰
，唐颖馨.内质网-线粒体交互作用与血管性痴呆的关系研究进展[J].神经损伤功能重建,2025,(2):111-113 |
| 内质网-线粒体交互作用与血管性痴呆的关系研究进展 |
| Research Progress on the Relationship between Endoplasmic Reticulum-MitochondriaInteractions and Vascular Dementia |
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| DOI： |
| 中文关键词: 内质网-线粒体 血管性痴呆 分子机制 线粒体-内质网结构偶联 |
| 英文关键词: endoplasmic reticulum-mitochondrial vascular dementia molecular mechanism mitochondria-associated endoplasmic reticulum membranes |
| 基金项目: |
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| 摘要点击次数: 309 |
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| 中文摘要: |
| 血管性痴呆（Vascular dementia，VD）是仅次于阿尔兹海默病的导致痴呆的原因，在中国占痴呆总数
15%。目前临床上针对VD治疗仅为药物对症治疗，不能有效预防和治疗VD。内质网和线粒体是细胞内重
要的细胞器，二者之间的交互作用在维持细胞稳态中起着关键作用。最新研究表明，内质网-线粒体交互作
用是VD发生的重要病理生理因素之一，但具体机制不明。研究VD的致病机制，探讨以内质网-线粒体交互
作用为靶点治疗VD的潜在策略，具有重要的临床意义。本文将对内质网-线粒体交互作用的分子机制、VD
可能的发病机制以及两者之间的关联做一综述。 |
| 英文摘要: |
| Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease, accounting
for 15% of dementia cases in China. Currently, clinical treatment for VD is merely symptomatic drug therapy,
which cannot effectively prevent and treat VD. The endoplasmic reticulum (ER) and mitochondria are important
organelles within cells, and their interaction plays a crucial role in maintaining cellular homeostasis. Recent studies have shown that ER-mitochondrial interaction is one of the significant pathophysiological factors in the development of VD, but the specific mechanisms remain unclear. Studying the pathogenic mechanisms of VD and exploring potential strategies targeting ER-mitochondrial interaction for VD treatment has important clinical significance. This article will review the molecular mechanisms of ER-mitochondrial interaction, the possible pathogenesis of VD, and the association between the two. |
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