| 杨雪
，李繁菊
，谢沁芳
，刘伟
，王满侠
，李晓玲.多发性硬化脑萎缩预测残疾和认知障碍的研究进展[J].神经损伤功能重建,2025,(1):45-48 |
| 多发性硬化脑萎缩预测残疾和认知障碍的研究进展 |
| Advances in Research on Predicting Disability and Cognitive Impairment in MultipleSclerosis with Brain Atrophy |
| |
| DOI： |
| 中文关键词: 多发性硬化 脑萎缩 残疾 认知障碍 |
| 英文关键词: multiple sclerosis brain atrophy disability cognitive impairment |
| 基金项目:甘肃省联合科研基
金（神经系统脱髓
鞘疾病相关生物标
记物探索和新型靶
向 药 物 研 发 ，No.
23JRRA1507)； 兰
州大学第二医院萃
英科技创新计划项
目（基于 FDA 药物
库的多发性硬化症
药物筛选与 Axl 分
子保护机制研究，
No. CY2021-MS-A
06） |
|
| 摘要点击次数: 50 |
| 全文下载次数: 48 |
| 中文摘要: |
| 多发性硬化（multiple sclerosis，MS）是中枢神经系统的炎性脱髓鞘疾病，其导致的残疾与认知障碍对
患者及社会造成较大的经济负担，早期预测及了解其疾病的发展方向有助于完善治疗方案。随着影像技
术的发展，对MS所致的中枢神经系统各结构变化的了解也更加全面、细致，越来越多的研究专注于通过影
像技术观察大脑各部位萎缩，从而说明其与残疾累积及认知障碍的关系。本文从大脑皮质、丘脑、基底神
经节区、小脑、脑干五部分综述大脑各部位萎缩与残疾和认知障碍的相关性。 |
| 英文摘要: |
| Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. The
disability and cognitive impairment caused by MS cause a great economic burden on patients and society. Early
prediction and understanding of the development direction of the disease are helpful to improve the treatment
plan. With the development of imaging technology, the understanding of the changes of the central nervous
system caused by MS is more comprehensive and detailed. More and more studies have focused on observing
the atrophy of various parts of the brain through imaging technology, so as to explain its correlation with the
accumulation of disability and cognitive impairment. This article reviews the relationship between brain atrophy
and disability and cognitive impairment from five parts: cerebral cortex, thalamus, basal ganglia area,
cerebellum, and brain stem. |
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