| The gut microbiota (GM), as a complex ecosystem, has an impact on the body's structure, endocrine level, metabolic capacity, nervous system, and immune function. At present, it has been found that the diversity of intestinal microbiota decreases sharply with age, and even undergoes harmful changes in functional structure, thus endangering the health of the elderly. The gut microbiota can be regulated, therefore, this review systematically analyzes the application of the gut microbiota in endocrine, musculoskeletal system, cognitive-psychological, neurological diseases, and viral infections in the elderly, and explores its underlying mechanisms. The aim of this study is to explore new ideas and potential targets for the treatment of related geriatric diseases, and to provide reference for future research on the intestinal microbiome. |