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| 细胞自噬在神经退行性疾病中作用的研究进展 |
| Research Progress on the Role of Autophagy in Neurodegenerative Diseases |
| 投稿时间：2024-12-04 修订日期：2024-12-04 |
| DOI： |
| 中文关键词: 自噬 信号通路 神经退行性疾病 |
| 英文关键词: autophagy signal transduction pathways neurodegenerative diseases |
| 基金项目:北京市自然科学基金(7222064, 7232003),国家自然科学基金(82071539) |
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| 中文摘要: |
| 神经退行性疾病的病理特征主要包括异常错误折叠蛋白质或多肽的积聚和沉积。自噬可以清除细胞内聚集蛋白和功能失调的细胞器,是延缓神经退行性疾病的重要靶点。自噬体产生或其成熟过程受损都会促进神经退行性疾病发生发展。深入了解调节细胞自噬的信号转导途径对于制定相关疾病的治疗策略至关重要。本文主要介绍自噬在神经退行性疾病中的重要作用及其相关分子机制。 |
| 英文摘要: |
| The pathological characteristics of neurodegenerative diseases mainly include the accumulation and deposition of abnormally misfolded proteins or peptides. Autophagy can clear aggregated proteins and dysfunctional organelles within cells, making it an important target for delaying the progression of neurodegenerative diseases. Impairment in the formation or maturation of autophagosomes can promote the occurrence and development of neurodegenerative diseases. A deep understanding of the signaling pathways that regulate cellular autophagy is crucial for devising treatment strategies for related diseases. This article mainly introduces the important role of autophagy in neurodegenerative diseases and its related molecular mechanisms. |
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