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| 自噬调控在精神分裂症中的研究进展 |
| Research Progress of Autophagy Regulation in Schizophrenia |
| 投稿时间：2024-11-17 修订日期：2024-11-17 |
| DOI： |
| 中文关键词: 自噬 精神分裂症 发病机制 抗精神病药物治疗 物理治疗 心理治疗 |
| 英文关键词: Autophagy Schizophrenia Pathogenesis Antipsychotic medication Physical therapy Psychotherapy |
| 基金项目:湖北省重点研发计划项目 |
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| 中文摘要: |
| 精神分裂症是机制不明的常见重型精神障碍,给社会和家庭带来沉重负担。近年来,大量的自噬与精神分裂症的相关研究提示自噬可能是精神分裂症病理生理过程的一部分,并且药物、物理、心理等治疗可能通过调控自噬缓解精神病性症状,使自噬调控成为治疗精神分裂症新方向。本文综述自噬与精神分裂症发病机制的关系,以及自噬在精神分裂症治疗方面的进展,为精神分裂症的诊疗探索提供新的思路。 |
| 英文摘要: |
| Schizophrenia, a common and severe mental disorder of unknown mechanism, imposes significant burdens on society and the economy. Recent studies have increasingly linked autophagy to the pathophysiology of schizophrenia, suggesting its potential role in the disease process. Regulation of autophagy through pharmacological, physical, and psychological means has been explored as a therapeutic intervention for schizophrenia, positioning autophagy modulation as a novel treatment approach. This paper discusses the relationship between autophagy and the mechanisms of schizophrenia, as well as advancements in autophagy-related treatments, with the aim of autophagy regulation emerging as a new therapeutic strategy for schizophrenia. |
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