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| 活性氧调控脊髓损伤后调节性细胞死亡的研究进展 |
| Advances of Reactive oxygen species in regulating regulated cell death after spinal cord injury |
| 投稿时间：2024-11-12 修订日期：2024-11-12 |
| DOI： |
| 中文关键词: 活性氧 脊髓损伤 调节性细胞死亡 凋亡 自噬 焦亡 铁死亡 |
| 英文关键词: reactive oxygen species spinal cord injury regulated cell death apoptosis autophagy pyroptosis ferroptosis |
| 基金项目:南京市卫生科技发展专项资金资助项目（ZKX22061，TiRobot机器人导航下微创行联合腱反转位解剖学重建喙锁韧带精准治疗急性肩锁关节脱位） |
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| 中文摘要: |
| 脊髓损伤(spinal cord injury, SCI)是一种常见的中枢神经系统损伤,会导致患者瘫痪甚至死亡,给社会带来了沉重的医疗负担。脊髓损伤的过程中会发生多种调节性细胞死亡(regulated cell death, RCD),如细胞凋亡、细胞自噬、细胞焦亡和细胞铁死亡等。活性氧(reactive oxygen species, ROS)是细胞代谢中氧不完全还原时产生的分子或自由基,在SCI过程中,ROS通过各种机制调控RCD,影响SCI的预后。本文综述了近年来ROS在SCI中调控RCD的机制,并为后续SCI的治疗提供了新思路。 |
| 英文摘要: |
| Spinal cord injury (SCI) is a common neurotraumatic damage, which may lead to paralysis or even death of the patients and give rise to medical burden on society. A variety of regulated cell deaths (RCD), such as apoptosis, autophagy, pyroptosis, ferroptosis and so on, occur in SCI. Reactive oxygen species (ROS) are molecules or free radicals produced during incomplete reduction of oxygen in cellular metabolism; During SCI, ROS modulate RCD through various mechanisms and affect the prognosis of SCI. This paper summarizes mechanisms by which ROS regulate RCD in SCI in recent years and provides new idea for subsequent treatment of SCI. |
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