文章摘要
陈黛琪，许艳梅，肖萍，李芳芳.抗BCMA CAR-T细胞治疗复发难治性AQP4-IgG血清阳性视神经脊髓炎谱系疾病的术后管理[J].神经损伤功能重建,2024,(11):639-643
抗BCMA CAR-T细胞治疗复发难治性AQP4-IgG血清阳性视神经脊髓炎谱系疾病的术后管理
Postoperative Management of Recurrent and Refractory AQP4-IgG SeropositiveNeuromyelitis Optica Spectrum Disorder (NMOSD) Treated with Anti-BCMA CAR-T CellTherapy
  
DOI：
中文关键词: 抗BCMA CAR-T细胞疗法  复发难治性AQP4-IgG血清阳性视神经脊髓炎谱系疾病  神经系统症 状  护理管理策略
英文关键词: Anti-BCMA CAR-T cell therapy  relapsed and refractory AQP4-IgG seropositive neuromyelitis optica spectrum disease  neurological symptoms  nursing management strategies
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作者单位
陈黛琪，许艳梅，肖萍，李芳芳 华中科技大学同济 医学院附属同济医 院神经内科 
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中文摘要:
      目的：总结11例复发难治性AQP4-IgG血清阳性视神经脊髓炎谱系疾病患者行抗BCMA CAR-T细胞 治疗后神经系统症状的管理经验。方法：对11例抗BCMA CAR-T细胞治疗回输后患者行一般护理观察、 细胞因子释放综合征、神经系统症状管理、心理护理、适时康复管理。结果：在中位随访5.5个月（范围1～ 14个月）期间，11例患者停用所有皮质类固醇和免疫抑制剂后实现无药物缓解均无复发；11例患者报告扩 展残疾评定和生活质量的改善。结论：回输后密切观察、早期发现神经系统症状并给予有效管理，减轻患者 痛苦，确保抗BCMA CAR-T细胞疗法治疗复发难治性AQP4-IgG血清阳性视神经脊髓炎谱系疾病临床顺利 实施。
英文摘要:
      To summarize the management experience of neurological symptoms in 11 patients with recurrent and refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorder (NMOSD) treated with anti-BCMA CAR-T cell therapy. Methods: General nursing observation, management of cytokine release syndrome (CRS), neurological symptoms, psychological care, and timely rehabilitation management were implemented for 11 patients after infusion of anti-BCMA CAR-T cells. Results: During a median follow-up period of 5.5 months (range: 1～14 months), all 11 patients achieved drug-free remission without relapse after discontinuing all corticosteroids and immunosuppressants. Additionally, all 11 patients reported improvements in the Expanded Disability Status Scale (EDSS) and quality of life. Conclusion: Close observation and early detection of neurological symptoms after infusion, coupled with effective management, can alleviate patient suffering and ensure the successful clinical implementation of anti-BCMA CAR-T cell therapy for recurrent and refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorder.
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