| Objective To explore the relationship between HbA1c and immune indicators levels and the degree of neurofunctional impairment in patients with cerebral infarction, as well as their predictive value for poor prognosis. Methods: This study was a retrospective study. A total of 65 patients diagnosed with acute cerebral infarction and treated at our hospital from January 2021 to February 2024 were included as the research group, including 22 mild cases, 22 moderate cases, and 21 severe cases. Another group of 65 patients who underwent health examinations during the same period were selected as the control group. The levels of HbA1c and immune indicators were compared between the research group and the control group, as well as among different severity groups. The relationship between HbA1c and immune indicators levels and the degree of neurofunctional impairment in patients with cerebral infarction, as well as their predictive value for poor prognosis, was studied. Results: The levels of HbA1c (t=2.995, P=0.003), CD3+ (t=54.917, P=0.000), CD4+ (t=28.993, P=0.000), CD8+ (t=7.740, P=0.000), CD4+/CD8+ (t=8.203, P=0.000), NK cells (t=7.804, P=0.000), CD19+ (t=10.929, P=0.000) in the research group were higher than those in the control group.The differences in HbA1c (F=18.188，P = 0.000), CD3+ (F=17.610，P = 0.000), CD4+ (F=20.638，P = 0.000), CD8+ (F=13.639，P = 0.000), CD4+/CD8+ (F=21.038，P = 0.000), NK cells (F=19.373，P = 0.000), CD19+ (F=14.979，P = 0.000) levels among different neurofunctional impairment groups were statistically significant.Comparing pairwise, the levels of these indicators in the severe group were higher than those in the moderate group and mild group.In the research group, there were 56 patients with good prognosis and 9 patients with poor prognosis.The HbA1c (t=4.531, P=0.000), CD3+ (t=6.839, P=0.000), CD4+ (t=8.096, P=0.000), CD8+ (t=8.829, P=0.000), CD4+/CD8+ (t=17.518, P=0.000), NK cells (t=4 .531, P = 0 .000) , CD19 + (t = 5 .171 , p = 0 .000) levels in patients with good prognosis were lower than those in patients with poor prognosis.There was a positive correlation between HbA1c and immune indicators levels and neurofunctional impairment.The analysis of the diagnostic sensitivity of HbA1c and immune indicators levels alone and in combination showed that the combined detection of these indicators had higher sensitivity than individual detection.In the combined detection model of patients, poor prognosis was taken as the dependent variable (Y), and HbA1c and immune index levels were taken as independent variables. In this study, Logit（Y）=0.156+1.203HbA1c+1.152CD3++1.082CD4++1.042CD8++11.037CD4+/CD8++1.123CD19++1.161NK细胞。NK cells.Conclusion: There is a positive correlation between HbA1c and immune indicator levels and the degree of neurofunctional impairment in patients with cerebral infarction. Through comprehensive analysis of these indicators, it is possible to effectively predict the poor prognosis outcome of patients and guide early clinical intervention. |