|
| 帕金森症状量表鉴别药物诱发的帕金森综合症（DIP）的可行性研究 |
| A feasibility study on the application of the Parkinson's Symptom Scale to identify drug-induced parkinsonism (DIP) |
| 投稿时间：2024-10-08 修订日期：2024-10-08 |
| DOI： |
| 中文关键词: 帕金森病 帕金森综合征 药物性 非运动症状 |
| 英文关键词: Parkinson's disease Parkinsonism drug-induced Non-motor symptoms |
| 基金项目: |
|
| 摘要点击次数: 55 |
| 全文下载次数: 0 |
| 中文摘要: |
| 目的：探讨使用帕金森症状量表(NMSS)鉴别药物诱发的帕金森综合症(DIP)与帕金森病(PD)的可行性。方法: 选取2023年5月-2024年5月就诊于我院神经内科的21例DIP、25未经药物治疗的PD以及22名无帕金森症状的患者。使用帕金森氏病综合评分量表(UPDRS III)和 Hoehn-Yahr量表(H＆Y)对患者进行评估；同时使用帕金森症状量表(NMSS)对非运动症状进行评估结果：DIP组与PD组比较,白天嗜睡和不宁腿、注意力集中、流涎、尿频夜尿增多、性功能障碍包括性欲改变及性行为不能、疼痛及味觉和嗅觉改变中NMSS存在显著性差异(P<0.05), DIP组评分明显低于PD组。相关性分析显示,运动症状与DIP为低到中度相关(rs = 0.254 - 0.519)。在NMSS的9个大项,30个小项中只有白天嗜睡、注意力不集中、尿急、尿频、夜尿增多、味觉及嗅觉改变与PD呈中等程度相关(RS = 0.370-0.497),不宁腿与其为低等程度相关 (RS=0.279)。其余项目均未发现显著相关性(P>0.05)。结论：NMSS评分可以较准确的鉴别早期DIP和PD患者。 |
| 英文摘要: |
| 0bjective: To investigate the feasibility of using the Parkinson"s Symptom Scale (NMSS) to to identify early drug-induced Parkinson"s syndrome (DIP) from Parkinson"s disease (PD). Methods: Twenty-one cases of DIP, 25 unmedicated PD, and 22 patients without Parkinson"s symptoms who attended our Department of Neurology from 2023 to 2024 were selected. The general condition of the patients was assessed, and a complete neurological examination, including the Integrated Parkinson"s Disease Rating Scale (UPDRS III) and the Hoehn-Yahr Scale (H Y), was performed. For non-motor symptoms, we assessed using the Parkinson"s Symptom Scale (NMSS). Results: There were significant differences (p<0.05) in the NMSS in sleep symptoms including daytime sleepiness and restless legs, concentration, salivation, urinary symptoms including urinary frequency and increased nocturia, sexual dysfunction including altered libido and inability to perform sexual acts, pain, and altered taste and smell, with the DIP group scoring significantly lower than the PD group. Correlation analysis showed that motor symptoms were low to moderate correlated with DIP (rs = 0.254 - 0.519). Of the 9 major and 30 minor items of the NMSS, only daytime sleepiness, poor concentration, urinary urgency, urinary frequency, increased nocturia, and altered taste and smell were moderately correlated with PD (rs = 0.370-0.497), and restless legs were lowly correlated with it (rs = 0.279). No significant correlation was found for the remaining items (p>0.05). Conclusion: The NMSS score can more accurately identify patients with early DIP and PD. |
|
View Fulltext
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|