| 赵旻超,
，胥方元.重复经颅磁刺激治疗原发性三叉神经痛新方案的疗效观察[J].神经损伤功能重建,2024,(10):579-583 |
| 重复经颅磁刺激治疗原发性三叉神经痛新方案的疗效观察 |
| Observation of the Efficacy of a New Protocol for Repetitive Transcranial MagneticStimulation in the Treatment of Primary Trigeminal Neuralgia |
| |
| DOI： |
| 中文关键词: 原发性三叉神经痛 重复经颅磁刺激 渐进递减式治疗方案 镇痛 |
| 英文关键词: primary trigeminal neuralgia repetitive transcranial magnetic stimulation progressive
decremental treatment protocol analgesia |
| 基金项目:宜宾市卫健委基金
资助项目（重复经
颅磁刺激治疗原发
性三叉神经痛药物
治疗后复发痛的时
效性研究，No. 202
1YW0030） |
|
| 摘要点击次数: 18 |
| 全文下载次数: 15 |
| 中文摘要: |
| 目的：本研究旨在探索一种新的重复经颅磁刺激（repetitive transcranial magnetic stimulation，rTMS）
治疗方案对原发性三叉神经痛（primary trigeminal neuralgia，PTN）的疗效。方法：PTN患者64例随机分为
对照组和治疗组，各32例。对照组给予常规卡马西平治疗，治疗组在卡马西平治疗的基础上，再给予渐进
递减式rTMS治疗（第1～2周，5次/周；第3～4周，2次/周；第5～8周，1次/周）；均治疗8周。设定患者入组
时间点为T0，每周治疗结束时分别记录为T1～T8。于T0～T8分别采用视觉模拟评分（visual analogue scale，
VAS）和简明疼痛评估量表（brief pain inventory，BPI）评估各时间点的疼痛相关指标；在T0、T4、T8时间点采
用匹兹堡睡眠指数量表（Pittsburgh sleep quality index，PSQI）评估睡眠质量，采用BPI疼痛对日常生活的影
响项目评估生活质量。结果：2组各脱失2例患者，最终各纳入研究30例。在T0和T1时间点，2组间的VAS
和BPI疼痛程度项目评分差异无统计学意义（P＞0.05）。T2～T8各时间点，治疗组的VAS、BPI疼痛程度项
目评分下降幅度明显大于对照组，差异有统计学意义（P＜0.05）。在治疗前，2组疼痛对日常生活影响项目
评分、PSQI评分差异无统计学意义（P＞0.05）。T4、T8时间点，治疗组的疼痛对日常生活影响项目及PSQI评
分下降幅度均明显大于对照组，差异有统计学意义（P＜0.05）。结论：本研究采用的rTMS治疗方案可以有
效缓解PTN患者疼痛，并降低疼痛对日常生活功能的影响，改善睡眠质量。 |
| 英文摘要: |
| This study aims to explore the efficacy of a new repetitive transcranial magnetic
stimulation (rTMS) treatment protocol for primary trigeminal neuralgia (PTN). Methods: Sixty-four patients
with PTN were randomly divided into a control group and a treatment group, each consisting of 32 patients. The
control group received standard carbamazepine treatment, while the treatment group was given a progressive
decremental rTMS therapy (5 sessions per week for weeks 1-2; 2 sessions per week for weeks 3-4; 1 session per
week for weeks 5-8) in addition to carbamazepine treatment. Both groups underwent an 8-week treatment
period. The enrollment time point was designated as T0, and at the end of each week (T1-T8), assessments were
recorded. Visual Analogue Scale (VAS) and Brief Pain Inventory (BPI) were used to evaluate pain-related
indicators at T0-T8. Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality at T0, T4, and T8, and
the BPI item assessing the impact of pain on daily life was used to evaluate quality of life. Results: Two
patients dropped out from each group, resulting in a final inclusion of 30 patients per group. There were no
statistically significant differences in VAS and BPI pain severity scores between the two groups at T0 and T1 (P>
0.05). From T2 to T8, the VAS and BPI pain severity scores decreased significantly more in the treatment group
compared to the control group (P<0.05). Before treatment, there were no statistically significant differences in
the scores of the impact of pain on daily life and PSQI between the two groups (P>0.05). At T4 and T8, the
treatment group showed a significantly greater reduction in the impact of pain on daily life and PSQI scores
compared to the control group (P<0.05). Conclusion: The rTMS treatment protocol adopted in this study can
effectively alleviate pain in PTN patients, reduce the impact of pain on daily living functions, and improve sleep
quality. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |